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NFL predictions and picks against the spread: Week 2: Chiefs have Ravens; Packers, Cowboys and Browns rebound

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Surprise results were not uncommon in Week 1, with many teams still unknown ahead of the 2021 NFL regular-season. It’s helpful to get some information and see what vibes each team is sending early.

This should make it easier for Week 2 to manage another full slate. It’s interesting to see three big favorites, while all the other matchups require one-possession spreads.

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No matter how large or small the number, this guide will help you get through it. We also hope to get some good, but not spectacular initial returns.

(Game Odds courtesy of fanDuel)

NFL Power Rankings: Huge bumps for Steelers, Saints and Falcons. But how about the NFC West?

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NFL Picks against Spread for Week 2.

  • Game of Week: Chiefs at Ravens (-3.55 o/u, 55.5 o/u).


Sunday, 8:20 pm ET, NBC

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When it was Andy Reid against John Harbaugh or Patrick Mahomes against Lamar Jackson, the Chiefs had won this series. Expect a similar result with Baltimore having just completed a week, and Kansas City being an aggressive traveling team. Jackson is more easily contained by the Chiefs than his Ravens counterparts. The Ravens don’t have as much experience with Mahomes, who throws downfield frequently to Travis Kelce and Tyreek Hill. Profiteer from the Chiefs’ low number.

Pick; Chiefs beat 27-23 to cover the spread.

  • Game of Midweek: Giants at Washington Football Team – -4, 41 o/u


Thursday, 8:20 pm ET, NFL Network

In Week 1, the Giants were an offensive disaster around Daniel Jones. Their defense was also poor at times and they gave way too often at the wrong time. Washington was also dealt a disappointing home loss by an AFC West team. Ryan Fitzpatrick also suffered a hip injury. Taylor Heinicke took over as QB. WFT has been a well-organized team defensively and offensively, under Ron Rivera. New York will have even more dysfunction without Joe Judge.

Pick – Washington wins the pick 20-13, and covers it.

  • Steelers (-6.5, 49.5 O/U) are the Lock of The Week over Raiders

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Sunday, 1 p.m. ET, CBS

Las Vegas is on the same page as Baltimore. They are coming off a week of playing deep into overtime and will now be heading to Pittsburgh, another AFC North rival. It is not clear that Derek Carr’s passing game will inspire the Steelers to handle their pass rushers and coverage. Although the Steelers lost offensively to the Bills, this game will provide a reprieve for their trio of talented wide receivers as well as a breakthrough opportunity for Najee Harris, their rookie running back in the first round.

Pick: Steelers win 31-14, and cover the spread

MORE The worst overreactions to NFL Week 1

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  • The Week’s Upset: Eagles win over 49ers (-3.5,50 o/u).


Sunday, 1 p.m. ET, Fox

It is impossible to ignore the Eagles’ dominance of Falcons in Week 1. The offense and Jalen Hurts provided everything the Eagles could need. They were very proactive and took care of the offense up front. Nick Sirianni already seems like a promising young coach in the Kyle Shanahan tradition. San Francisco’s Shanahan has been a good coach, although their ineptness late in Detroit may not have carried over to Philadelphia. In the 49ers defense, the Eagles will have many of the same opportunities that the Lions had. But at a much higher level.

pick: Eagles win 27-24

  • Bengals at Bears (3, 45.5 o/u


Sunday, 1 p.m. ET, Fox

They are doing their offense no favors by messing with their quarterbacks. While they can run the ball with David Montgomery and their rookie first-rounder Justin Fields, they will not be able to tap into their full potential as a passing team until then. Joe Burrow is also concerned about Chicago’s poor pass defense against Rams receivers. Cincinnati’s three-man offensive line can be dangerous. To defeat the Vikings, the Bengals used a run defense and a pass rush in crucial situations. Cincinnati remains a pleasant surprise in the early season, and Andy Dalton will be watching closely while Matt Nagy watches.

Bengals Win 24-20

  • Texans at Browns (-12.5 & 48 o/u).


Sunday, 1 p.m. ET, CBS

Tyrod Taylor did a great job in helping Houston overcome its Deshaun Watson issues in Week 1. His leadership skills are excellent, and he has dual threat abilities that include an athleticism and strong arm. He now has a chance to “revenge” the Cleveland team, which he was beaten by four years ago when Baker Mayfield replaced him. The Texans face a much more dangerous offense this week, which also focuses heavily on their run defense weaknesses with Kareem and Nick Chubb. Mayfield will be able to change the story, as Taylor is prevented from making a Mahomes-like comeback by the Browns’ defense.

Pick Browns Win 38-21 and Cover the Spread

MORE The debut of the rookie QB is made starting in Week 1


  • Colts Rams (47.5, 47.5 o/u).


Sunday, 1 p.m. ET, Fox

Matthew Stafford is the Rams’ new quarterback. These same feelings are being held by the Colts for Carson Wentz. Indianapolis faces another tough home match against an NFC West offensive power. This one will be led by Aaron Donald, Jalen Ramsey and a stronger defense. The Colts will be contained by Jonathan Taylor running the game and won’t have any weapons to counter Stafford. The defense of the Colts was stifling against Sean McVay’s Seahawks-adjacent offense.

Pick: Rams win 27-17, and cover the spread.

  • Dolphins Bills (-3.5, 47.5, o/u).


Sunday, 1 p.m. ET, Fox

With the Steelers’ defense blocking Josh Allen, the Bills had to lose their offensive mojo. Tua Tagovailoa provided just enough offense for the Dolphins to beat the Patriots. Both Buffalo and Miami have shown strong defenses during their victories. This will make this a low-scoring game between division rivals. As Allen is trusted with key plays and his leg over Tagovailoa, the Bills can scratch this game.

Pick: Bills win 23-20, but do not cover the spread.

  • Patriots (42.5, -5.5 o/u at Jets


Sunday, 1 p.m. ET, CBS

With Bill Belichick, the Patriots are a formidable team against rookie quarterbacks. The Panthers will provide plenty of game footage on how to stop a young Zach Wilson. New England will not be concerned about running and instead focus on Wilson’s top target, Corey Davis. Mac Jones, the rookie counterpart, has more help with his running game, offensive line and flexible support skill personnel, which allows him to keep the ball moving in a methodical, error-free manner.

Pick, Patriots win 24-13 and cover the spread

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  • Saints at Panthers: -3, 44.5 O/U


Sunday, 1 p.m. ET, Fox

They won an emotionally charged victory against the Packers by dominating them in Jacksonville. Alvin Kamara and Christian McCaffrey will be fighting for the championship in Carolina. This is due to the fact that Alvin Kamara has the better offensive line. Jameis Winston will also win because he can make the big plays downfield. Saints know what Joe Brady wanted to do and that will help them to be able to provide a solid defense during transition.

Pick: Saints cover the spread 24-20

  • Broncos (-6, 45.5 o/u) at Jaguars


Sunday, 1 p.m. ET, CBS

Although the Broncos won with their running and defense, they were beaten by the Giants in passing. However, Teddy Bridgewater lost a crucial target with Jerry Jeudy getting a high ankle strain. The pressure package to Vic Fangio’s defensive stud Von Miller has been boosted by improved coverage. After Trevor Lawrence’s running game has been contained, Miller will be a rattlesnake. Denver does not need to change its winning formula against a lesser team. Jacksonville will continue to build off its strong second half against Texas. Urban Meyer may be more involved in Jacksonville’s success, but that is about it at 0-2.

Pick: Broncos 24-20 but do not cover the spread.

  • Vikings at Cardinals (-3.50, 51 o/u).


Sunday, 4:05 pm ET, Fox

It was expected that the Vikings would be more defensively sound, particularly up front. With J.J. Watt, Chandler Jones and a healthier Chandler Jones, the Cardinals are much better at defensively. To complement the run-heavy strategy of Dalvin Cook, Minnesota does have more firepower than Tennessee. DeAndre Hopkins will be handled by former Cardinal Patrick Peterson, who is still a strong advocate for the cause. However, Kyler Murray, a longtime friend, has many more tools than Kirk Cousins. Arizona beats Minnesota in the desert, improving its record to 2-0.

Pick – Cardinals win 30 – 27 but do not cover the spread

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  • Buccaneers at Falcons (-12.5, 52 O/U)


Sunday, 4:05 pm ET, Fox

In the opening game, the Falcons were terrible offensively. Arthur Smith might have made Matt Ryan uncomfortable by forcing him to run against the Eagles. Ryan will adjust by letting loose with his wide receivers as well as hybrid tight end Kyle Pitts. Passing on the Bucs is much easier than running on them. After Tom Brady has done a lot of damage again with his tight ends and wideouts, the Bucs will have no problem stopping any division spoiler from returning.

Pick: Buccaneers win 21-21, but do not cover the spread.

  • Cowboys at Chargers (-22.5, 55 o/u


Sunday, 4:25 PM ET, CBS

Dak Prescott’s victory at Tampa was a huge win for the Cowboys. He will have a week off to strengthen his shoulders in preparation for Week 2. Dallas views L.A. as a place to call home, away from Oxnard (Calif.), and there should be plenty of people at SoFi Stadium. Dallas and Ezekiel Elliott will be more successful running the ball in this match, which should open up opportunities for Amari Cooper and CeeDee Lamb to pass the ball. Justin Herbert will have more success running the ball with Los Angeles’ skill players than he did in Washington. This should lead to another thrilling game where Prescott defeats him.

Pick: Cowboys win with 34 to 27

  • Titans at Seahawks (-55.5, 53.5 O/U)


Sunday, 4:25 PM ET, CBS

Problem: The Titans are having a hard time. The Titans defense relies on their young secondary to protect them against a weak pass rush. The offense is game-script dependent, meaning they only work when Ryan Tannehill or Derrick Henry are running fast. With Russell Wilson’s performance, the Seahawks took advantage of the Colts run-heavy offense and were able to score in the second quarter. Henry should run more this week in order to keep the Titans alive, however Wilson should ensure Seattle is 2-0 at home by late comeback, if necessary.

Pick. Seahawks win 31 to 27, but do not cover the spread.

  • Lions against Packers (11.5, 48.5 o/u


Monday, 8:15 PM ET, ESPN

Since Matt LaFleur has been a clunker for the Packers, they can expect a similar performance in 2021. These players tend to rebound from tough spots in the get-well game. Aaron Rodgers will play Aaron Jones in this game, while Aaron Jones and the defense at Lambeau Field will also be there. Detroit will not have any back-door protection against an NFC contender.

Pick: Packers win 38-14, and cover the spread.


Vinnie Iyer’s 2021 picks:


  • Week 1 Record against Spread: 8-7

  • Week 1, record right up: 9-6

  • Season: 8-7

  • Season right up: 9-6

Publiated at Tue 14 Sep 2021, 08:52.17 (+0000).

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