Wiltshire Police said the crash took place on the A4 in Derry Hill, near Calne, at 3am. A vehicle crashed into the side of a house and subsequently caught fire. The occupants of the house immediately called 999 and were evacuated while the fire service extinguished the blaze.
Nobody inside the house was injured.
The four occupants of the vehicle – all young males from the local area – died at the scene, police said.
Superintendent Steve Cox, of Wiltshire Police, said: “This was an absolutely horrific collision on our roads in the early hours of this morning.
Four young men have been killed after a crash on the a4
Nobody in the house was injured
“All blue light services attended the scene and were met with devastating scenes after a vehicle travelling along the A4 collided with a house and caught on fire.
“All four occupants of the vehicle died at the scene. Their families have been informed and we are in the process of assigning each family with specialist trained officers.
“My thoughts and the thoughts of all at Wiltshire Police are with them all today.”
Police said the A4 and the A342 remain closed
The car crashed and caught fire
Police said the A4 and the A342 remain closed while investigation and recovery work is ongoing at the scene of the collision.
Officers are appealing for anyone with information to get in touch.