A 48-year-old man has died following the crash in south Wales, according to local police. The incident occurred on the A465 between the Neath Abbey and Tonna junctions.
South Wales Police said a black Aygo clashed with a red VW Beetle and a male pedestrian.
A police spokesman said: “Following the collision and despite the best efforts of the emergency services a 48-year-old male was declared deceased at scene.
“At present the road remains closed for investigation work to be carried out and South Wales Police would like to thank the community for their patience and understanding during this time.
“South Wales Police would like to speak with any witnesses to the collision, any person who may have dash cam footage of the incident or anyone who witnessed the manner of driving of the Toyota Aygo prior to the collision.
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“Please could witnesses contact South Wales Police on 101 quoting occurrence 1900472034.”
It comes as the M1 was shut again after a third serious crash in less than 24 hours, involving “multiple vehicles”.
The southbound carriageway of the M1 was closed in West Yorkshire following a “serious incident” involving “multiple vehicles”.
This is the third major crash on the motorway in 24 hours.
West Yorkshire Police said on Twitter on Christmas Day: “The M1 south bound is closed from junction 40 to 39 due to a RTC involving multiple vehicles.
“It is expected to be closed for several hours.
“Please avoid the area if you can.”
The incident follows a fatal collision 140 miles further south in Bedfordshire, late on Christmas Eve.
A woman, who has not been named, was pronounced dead at the scene following the crash.