Officials confirmed a man had died at the scene and the young girl died later in hospital.
A resident claimed the emergency services arrived at around 8am on Saturday.
Carl Goodfellow, described how he could hear shouting and witnessed smoke billowing out of the house on Wensley Avenue.
He tried to warn the occupants of the house by banging on the door and shouting through the letterbox but said it was “to no avail”.
Mr Goodfellow said: “It’s devastating, you just don’t expect this sort of thing do you.
“I know him as a neighbour, we sent each other Christmas cards and stuff, but hadn’t been inside each others houses or anything.”
Humberside Police have cordoned off the affected house on Wensley Avenue, keeping it cordoned off until around 11.30am.
A team of fire investigation dogs deployed by Humberside Fire and Rescue Service are also at the scene helping officers with the investigation.
More to follow…