Around 80 firefighters are at the scene as half of the first and second floor of a three story building on Wadsworth Road are alight.
Crews were called to the scene at 11:35pm with 12 fire engines sent to the blaze.
One witness of the blaze shared a video of firefighters at the scene.
They tweeted the video with the caption: “Whole area is really a no go zone.”
Another twitter user from Perivale, Vinesh Pomal, added: “Is there an exclusion zone? There are residential properties near by and the smell is toxic!”
London Fire Brigade tweeted: “Residents in the vicinity of the warehouse fire in Perivale are advised to keep their doors and windows closed due to heavy smoke in the area.”
The brigade said in a follow up tweet: “Crews are making steady progress at the scene of the Perivale warehouse fire.
“Residents are still advised to keep doors and windows closed as firefighters work to bring the blaze under control.”
People in the area also took to social media to share their concerns over the fire.
Natalie Wall tweeted: “The smoke and smell is so bad.”
Another Twitter user said: “I’m smelling this right now as well, it’s a very strong smell out on the stress right now!”
The cause of the fire is not known at this stage.
As the flames tore through the structure, plumes of thick black smoke were visible across London.
About 30 people were evacuated from the warehouse but there were no reports of any injuries.
People living nearby were also advised to close windows and doors due to the copious amounts of smoke billowing from the blaze.
The inferno was brought under control by midnight, claimed the London Fire Brigade.
Station manager Jeff Lisle who was at the scene said: “Crews worked very hard in extremely difficult conditions to bring this fire under control.
“Firefighters used aerial ladder platforms to tackle it from numerous vantage points and to prevent the blaze from spreading to neighbouring warehouses.
“Although not in a residential area the smoke from the fire was travelling quite a distance so we advised locals to keep windows and doors shut as a precaution.”
A witness told the BBC he could see the heat from his bedroom window which he found “quite scary”.
Around 45 firefighters remained at the scene the next day damping down the fire.