Research into the potential benefits of curcugen, a turmeric-based formula used to improve plasma absorption and clinical efficacy, found the extract delivers 31-fold higher quantities of compounds into the bloodstream.
This prevents the compound from having an effective impact on the body, making it difficult for human to reap turmeric’s full benefits.
Curcugen is an extract designed to facilitate maximum levels of curcuminoids absorption.
Its composition is derived from turmeric and concentrated curcuminoids.
Researchers who led the study, published in Medicine, set out to evaluate the efficacy of therapeutic claims of curcugen during trials which took place at the team’s criminal pharmacology unit.
A total of 16 blood samples were collected from participants to quantify levels of turmeric compounds.
Findings showed a significant difference between treatment with curcugen versus the standardised curcuminoids extract.
The data analysis supported the ‘primary efficacy measure’ that a single oral dose of curcugen can significantly increase absorption when administered under fasting conditions.
Turmeric has been used in India for thousands of years as both a spice and medicinal herb.
Researchers have recently started to back up traditional claims that turmeric contains compounds with medicinal properties.
It is a natural inflammatory compound that can help fight foreign invaders and has a role in repairing damage in the body.
Scientists believes that chronic low-level inflammation can play a role in some health conditions, including:
Carious degenerative conditions
The spice has a warm, bitter taste and is frequently used to flavour or colour curry powders, mustards, butters and cheeses.
Because curcumin and other chemicals in turmeric might decrease swelling, it is often used to treat conditions that involve pain and inflammation.
The compound has also been studied as a beneficial herb in cancer treatment and has been found to affect cancer growth and development.
Since it is poorly absorbed into the blood stream, health experts recommend consuming it with black pepper, which contains piperine, a natural substance known to enhance the absorption of curcumin by 2,000 percent.
The compound is also fat soluble, which means it breaks down and dissolves in fat or oil, so health experts also recommend takin curcumin supplements with a meal that’s high in fat.
Stinging nettles are “quite remarkable”, remarked Roy Lamb. A rich source of omega-3, essential amino acids, vitamin A, calcium, and fibre, the nutrient-dense plant can prolong longevity. Its omega-3 content, which “plays a vital role in controlling cholesterol”, matches that of spinach. Nettles also contain “almost the same amount of amino acids as chicken”, so it’s abundant in its muscle-building capability.
While nettle has been part of traditional medicine for eons, scientific research is now providing vital evidence that the plant could have life-enhancing effects.
Lamb said there’s nothing wrong with picking weeds from the garden, as long as you wash them off and boil them before you add the plant to your meals.
However, if you’d rather a more simplistic way of enjoying the health benefits of nettles, Lamb recommends the Emunity detox health drink.
Easily drinkable from a can, Emunity harnesses the healing properties of the weed without the fuss.
Nintendo is a company that has never been particularly good at communication. But it is a company that is good at learning from their errors. You remember that infamous Skyward Sword demo at E3 2010, right? The one where Miyamoto walked out onstage, waggled his controller around, and couldn’t get it to work (that sounded dirtier than I meant it to)? It’s no surprise that the following year Nintendo began using pre-recorded Nintendo Directs, meaning it wouldn’t have to undergo live demo humiliation again.
The last few years have seen Nintendo adopt an unprecedented new approach, where partnerships with a variety of companies are forged, with their approach to communication with fans changing significantly. Nintendo Directs, originally developed under the direction of Satoru Iwata, allowed for communication directly with fans; whilst the company’s approach to fan events and community creation based on Nintendo franchises is behind where we would want it to be, its focus on game development software like Super Mario Maker and the recent Game Builder Garage shows a level of willingness for ‘other people’ to make Nintendo-like games.
Let’s not pretend that Nintendo is as free with their IP as companies like Sega, as Nintendo is still notorious for being one of the most secretive companies in the gaming industry. But recently, the company has branched out, working with a range of partners on a variety of multimedia projects and opportunities that it would no doubt have shirked in the past. These partnerships look to be bearing fruit already, as Nintendo’s original deal with Illumination to make a Mario movie has seen Illumination’s CEO, Chris Meledandri, join Nintendo’s company board in a non-executive role.
More unusual for Nintendo is that it’s also looking to provide further context and understanding of its history. There have been a number of unofficial books and documentaries that have provided insight into the history of this private company, but for the first time ever Nintendo will be taking control of how its history is represented through the development of an official Nintendo Gallery Museum, opening in Japan in 2024.
It’s pretty significant that a games developer and publisher will have its own space dedicated to displaying and explaining its heritage to the general public. No other platform holder has their own museum, making for quite a bold statement about Nintendo’s significant place in the games industry. It’s also a much more expensive step to take compared to prior initiatives like the classic Iwata Asks series, although the new ‘Ask The Developer’ series is looking to capture the spirit of Satoru Iwata’s revealing interviews, as well. Whether the preservationist interest generated by the ‘gigaleak’ hack has impacted the company’s approach to making its archived material more publicly available is unknown but, if nothing else, that unfortunate episode demonstrated the insatiable thirst Nintendo fans have for behind-the-scenes development materials.
But it’s not just Nintendo getting in on the act. Ex-Nintendo employee Toru Hashimoto has recently opened his secret Tokyo Nintendo café, 84, to the general public for the first time. At first, the café was only accessible to Nintendo employees and big-name Japanese games developers, featuring an incredible selection of Nintendo memorabilia, and exclusive artwork and doodles from Japanese developers such as Yuji Horii, designer of the hugely influential Dragon Quest series.
Whilst Hashimoto cites the need for change as a result of the impact on the hospitality industry due to the COVID-19 pandemic, it means that Nintendo fans can one day sit in the same seats as some of the greatest Japanese game developers of all time, an opportunity many will jump at the chance to have.
So then, let’s ask the question you’re all here for: what does this mean for Nintendo’s content going forwards?
To start with, the company will increase investment in their partners, not just with games developers but across other media formats such as movies and TV. We’ve already begun to see the fruits of its more aggressive approach to licensing with a steady increase in merchandising, its Super Nintendo World theme park, and the in-production Mario movie, but this means that we might one day get to see that rumoured Legend of Zelda Netflix show, or something in that vein. It’s likely that we’ll see more Nintendo franchises receive the same treatment in the future, with Mario movies sitting alongside Zelda or Metroid content (Smash Bros. style MCU, anyone???).
Nintendo feeling more comfortable handing out their licenses to other companies, we could also see a wider variety of games developed outside of Nintendo’s hands
But with Nintendo feeling more comfortable handing out their licenses to other companies, we could also see a wider variety of games developed outside of Nintendo’s hands. It’s something the company has tested the waters with in the past, giving independent developers the chance to license out their gaming IP, such as utilising the Zelda franchise in Cadence of Hyrule. Handing over full control of main franchise entries hasn’t always worked well in the past (looking at you, Metroid: Other M!) but things are looking promising for their partnership with MercurySteam for the long-awaited Metroid Dread.
At times, it has felt like Nintendo has had too many plates spinning as it handled development on multiple systems, resulting in a noticeably lower output during the Wii U/3DS era. Focusing primarily on Switch has helped smooth development pipelines to an extent, but there are still regular gaps in the Switch release calendar, especially when it comes to the larger releases. This is why Nintendo partners with companies like Bandai Namco on various projects, but if more of the regular ‘big’ Nintendo games were developed either externally or in collaboration with other developers, we could see a more consistent release schedule of Nintendo games from their third-party partners, resulting in increased opportunity for Nintendo’s internal teams to develop their own new franchises.
For me, some of the most interesting Nintendo releases of the last few years have been new IP like Splatoon and ARMS and it seems like this is also a priority for Nintendo, with President Shuntaro Furukawa previously confirming that in the future Nintendo will increase their “work on new games and series”.
Obviously, none of these actions are entirely new. At different times throughout Nintendo’s history, the company has made efforts to bring its franchises to people outside of the video games sphere, and partnered with various organisations to make that happen. We all remember the classic Super Mario. Bros movie, don’t we? Ugh. The fallout from that lapse in judgement arguably turned the company overcautious when it came to IP licensing. Or how about the Zelda CD-i games? Double ugh.
But this time, it really feels like there’s more of a strategy to it. By working to bring Nintendo content to theme parks, the big screen, and even to a museum audience, Nintendo as an organisation is becoming much more open. And that’s a good thing for everyone.
The development in technological advancements is a boon for every commoner. You can now do everything online by just touching a few buttons. From booking tickets to shopping, you will do everything swiftly. As far as airline reservation is concerned, the benefits are a lot.
You will not find it necessary to rush to your preferred airport to stand in queues for check-in. Today, you may handle every activity without leaving the comfort of your home because many airlines offer e-check-in options. Some of the benefits of booking a flight online include:
1. Cancelation and Changes of Travel It is normal for travelers to cancel or change their online reservations. They will not have to call their airlines and wait for a service representative to give them a hand. Booking a flight online means you may do everything provided have internet access. Some airlines offer bookings without cancellation fees, while others provide online cancellations and changes for free, as long as you do it within 24 hours of departure.
2. Early Check-Ins If you want to fly within the country, you might check-in in advance and as late as one hour before taking your flight. On the other hand, international flight booking allows travelers to check in between three and 24 hours before taking their flights. All you need to do is visit the site of your preferred airline and find your reservation so that you can enter your details. Main airlines also provide mobile check-in options, where travelers will receive a bar code on their phones.
3. Maximize Efficiency There are a lot of aspects of booking online, which have been automated. Time is valuable, and all the time you spend unnecessarily to put information into booking flights can be spent assisting customers in the queue. Strong online booking tools, such as TTS WeBook, are a great way to take the workload off yourself. By setting a customized page, you will make sure that you get all the details you require to secure bookings.
4. Special Amenities or Deals From time to time, airlines provide loyalty bonuses and other additional benefits for online booking. These may range from free Wi-Fi, beverage credits, and food to additional miles and special packages. These benefits and deals will motivate you to book directly since they might not be available through third parties.
5. Time Saver and Less Hectic The internet has everything, so you may easily create packages from scratch based on your personal preferences, dates, and budget. You will also find affordable flights ready tailored to concert tickets, booking hours, and museums. Hence, there will be no need to reach out to a representative and wait to receive feedback. Online booking allows you to reserve a seat any time of the day.
In a Nutshell! Bygone are the days when a traveler was required to visit a nearby local travel agent so as to book a flight. Today, you no longer have to visit a travel agent as you can book a flight at the comfort of your sofa.
If you are always busy and still want to take a trip with your family overseas, ensure you book your flight and get tickets online.
Although adolescents with acne received different cumulative doses of isotretinoin based on their body mass index, there were no differences in acne clearance, relapse, and most side effects between normal-weight, overweight, and obese individuals, a retrospective cohort study found.
“Oral isotretinoin is among the most effective treatments for acne and is indicated for the treatment of severe acne or when first-line regimens have failed,” Maggie Tallmadge said at the annual meeting of the Society for Pediatric Dermatology. In adolescents with acne, isotretinoin is prescribed at a dose of 0.5-1 mg/kg per day “with the goal of reaching a cumulative dose of 120-150 mg/kg and clinical clearance with durable remission,” she said. “Most providers do not prescribe a daily dose over 80 mg due to perceived increased risk of side effects, including xerosis, cheilitis, liver dysfunction, and acne flare. However, many adolescents weigh over 80 kg and are therefore effectively underdosed, prolonging treatment time and possibly increasing the risk of side effects due to prolonged therapy.”
To evaluate differences in treatment courses among normal-weight, overweight, and obese adolescents, and the efficacy and safety of treatment, Tallmadge, a third-year medical student at the Medical College of Wisconsin, Milwaukee, and colleagues completed a retrospective chart review of 550 dermatology patients at Children’s Wisconsin, also in Milwaukee, who completed at least 2 months of isotretinoin treatment for acne when they were between the ages of 10 and 24, from November 2012 to January 2020. They collected data on age, weight, height, daily dose, cumulative dose, time to acne clearance, side effects, and acne recurrence after treatment, and classified patients as normal weight, overweight, or obese based on their body mass index for age percentile.
Of the 550 patients, 367 (67%) were normal weight, 101 (18%) were overweight, and 82 (15%) were obese. The median age of those in the normal-weight and overweight groups was 16, and was 15 in the obese group.
There was were significant differences in the median cumulative dose in each weight group: 143.7 mg/kg for normal-weight patients, 138.2 mg/kg for overweight patients, and 140.6 mg/kg for obese patients (P < .001).
“Despite achieving different cumulative doses, there was no difference in acne clearance, relapse, and most side effects among the three [body mass index] cohorts,” Tallmadge said. “Thus, it appears that current treatment strategies may be appropriate for overweight and obese adolescents.”
The proportion of patients with acne clearance did not differ significantly among the three groups of patients: 62% who were in the normal weight range, 60% who were overweight, and 59% who were obese had clearance of facial acne with treatment (P = .84).
Of patients whose treatment course was completed by the time of data collection, the proportion with acne recurrences was similar between the three groups: 25% of normal-weight patients, 27% of overweight patients, and 35% of obese patients (P > .05). Of patients whose treatment course was completed by the time of data collection, there was no significant differences in acne recurrence: 25% of normal-weight patients, 27% of overweight patients, and 35% of obese patients.
However, the proportion of patients reporting headaches differed significantly between the groups: 29% of normal-weight patients, compared with 40% of both overweight and obese patients (P = .035). The researchers also observed a significant positive correlation between increased BMI and increased triglyceride and ALT levels during treatment (P < .001 for both associations), yet no elevations required clinical action.
Funding for the study was provided by the MCW Medical Student Summer Research Program and the American Acne & Rosacea Society.
This article originally appeared on MDedge.com, part of the Medscape Professional Network.
Collagen supplements are recommended to people who want to reduce signs of ageing, as it is often thought that it’s better to take collagen rather than apply it to your skin. But are they actually safe to take?Express.co.ukchatted to Dr Deborah Lee at Dr Fox Pharmacy to find out everything you need to know about taking collagen supplements.
Collagen is a protein produced in your body and it’s very important because it makes up about 30 percent of the body’s total protein content.
You may have heard of collagen in relation to the skin and ageing, but that’s not all it does.
Dr Lee explained: “Collagen is the major component of connective tissue – this is the scaffolding that holds us together.
“It is found in skin, hair, teeth, joints, ligaments, muscles and bone. Without collagen, our bodies would literally fall apart.
“Your body synthesises collagen using amino acids from the food you eat.”
In the UK, the Advertising Standards Agency has been critical of adverts which lead the consumer to believe collagen supplements result in younger-looking skin, as there is a lack of medical evidence that this is the case.
The European Food Safety Authority have also come to similar conclusions.
Dr Lee said: “Most of the studies on collagen and health are short term, include few participants, and often lack a control (placebo) group.
“Taking collagen supplements can result in side effects such as acid reflux, nausea, stomach pains and diarrhoea.
“They are derived from fish, so do not take them if you have a fish or seafood allergy.”
Otherwise, Dr Lee said collagen supplements appear to be safe to use.
The best way to supplement your own collagen isn’t necessarily through taking it in supplement form.
Dr Lee advised: “Eat a healthy diet with a sufficient quantity of high-quality protein.
“This is found in meat, poultry, fish, eggs, and soya, as well as ingesting plenty of plant-based proteins from whole grains, beans, pulses, nuts and seeds.
“Vitamin C is essential for the production of collagen, so another way of boosting your own collagen levels is to eat more vitamin C.”
The DVLA says “more and more licence holders” are now choosing the online service as drivers can secure a range of benefits. New figures from the DVLA show around six in 10 over 70 year olds now use the online tool.
“The next time you need to renew your driving licence, our advice is to try the online service and see for yourself just how easy and convenient it is.”
As well as saving on the price of posting off an application, drivers can also benefit from quicker delivery times.
Whereas a postal application could take weeks for a new driving licence to arrive, the online service promises delivery within five days.
UsingGOV.UKcustomers can be assured they are dealing with the official DVLA and that applications are safe and secure.
She said: “It is fantastic to see more drivers over the age of 70 choosing to renew their licences online.
“The sharp increase in online renewals since 2016 is testament to how quick and easy this process is and I hope the trend will continue as more people choose to experience these benefits for themselves.”
Drivers can renew an expired driving licence through the GOV.UK website for just £14.
However, drivers renewing ebcaise they resch 70 years old do not need to pay for tehir new card.
Sense of balance tends to deteriorate as you get older and this can cause you to lose self-confidence for many reasons. A stooping posture can negatively affect self-esteem, for example. Research also suggests balance can influence your life expectancy.
Dr Michael Mosley cited a study on his BBC podcast Just One Thing with Michael Mosley that found a “clear relationship” between how long people in their 50s could stand on one leg with their eyes closed and whether they would be alive 13 years years later.
The Medical Research Council tracked 5,000 people born in 1946 throughout their lives.
At the age of 53, they completed the tests during home visits from specially trained nurses.
In the standing on one leg with eyes closed test, men and women who were able to hold the position for less than two seconds were three times more likely to die before the age of 66 than those who could hold it for 10 seconds or more.
Those unable to do the test at all were more likely to die in the following 13 years.
Dr Rachel Cooper at the Medical Research Council said: “The majority of these studies are done in older people but we have shown that even in this younger age group, where you would not expect pre-existing disease, we are still seeing these measures are picking up some underlying ageing and disease process.”
Drilling down further into the possible explanations for this association, Dr Mosley spoke to Professor Dawn Skelton at Glasgow Caledonian University.
One possible explanation is that people are more prone to falling, incurring serious injuries, Dr Skelton said.
Our gut microbiome is always in a delicate balance and many factors can disrupt the composition.
Dr Stephens explained: “The microbes in our gut support us day to day- in fact, we couldn’t live without them!
“However, some of these microbes can cause harm when their numbers increase.
“They need to be kept in check and outweighed by plenty of good, friendly bacteria.”
Unfortunately, the western lifestyle is not very microbiome friendly and there are many factors that can reduce the number of friendly bacteria, providing more space and nutrients for these potentially harmful microbes to thrive.
Stress, antibiotics, high sugar and fat diets, low fibre intake, travel, pesticides, smoking, reduced exercise, caesarean sections and poor sleep cycles (e.g. shift work) are just a few examples of things that cause an imbalance in the gut, also known as microbial imbalance dysbiosis.
Dr Stephens explained: “When dysbiosis occurs, you may see some very recognisable side effects: constipation, bloating, diarrhoea, abdominal pain, low immunity, fatigue, low mood and poor skin- to name a few!”