Tag Archives: factors

Pent-up demand is only one of the factors driving up the cost of every step of the travel journey

Pent-up demand is only one of the factors driving up the cost of every step of the travel journey
Hotel rooms? Up about 44% at the end of June compared to a year earlier, according to data from hotel research firm STR. Air fares? They were 24% higher in May than in the same month last year, according to the Consumer Price Index.
Even so, many of the prices are still below where they stood in the summer of 2019, six months before the outbreak of the Covid-19 pandemic brought demand for travel to a near halt and sent prices plunging.
“Most of what people are seeing in price inflation is due to how cheap things were last year,” said Adam Sacks, president of Tourism Economics.
Most in the industry avoid making the year-over-year comparisons in the CPI. Instead they’re looking at the contrast with the 2019 price and booking levels.
But even some of those prices are back to near or even above 2019 levels, thanks to the strong rebound in demand. For example, STR shows the national average for US hotel rates in the week ending June 26 back to 99.5% of where they were at the same time in 2019.
“That’s an incredible run,” said Sacks. Only two weeks ago they stood at 93% of 2019 levels, he added.
The national average disguises some even bigger increases in vacation destinations.
“The price differences are pretty disparate,” Sacks said. “The national prices don’t really mean anything when you’re looking to travel to a specific location at a specific time.”
He said that in locations where the travel and tourism industry depend on business travel, such as New York, Chicago and Washington, prices are still well below 2019 levels, since business travel has been much slower to return than leisure travel. That suggests fare increases for leisure travelers are likely even greater than the overall numbers show, he said
“If business travel was performing anywhere near what it was in normal times, we’d be seeing record performance,” said Sacks.
Popular vacation destinations have hotel prices already going above 2019 levels. In Orlando, prices are up 6%, and in Miami they’ve jumped 48% during the week ending June 26 compared to the same time two years ago. But if you’re going to New York City, traditionally a center for business travel which also has yet to reopen Broadway shows, a major tourist draw, hotel prices are 25% below where they were in the same week of 2019, according to data from hotel research firm STR.
“You see pent-up demand to get back out on vacation pushing up travel, and prices,” said Vivek Pandya, senior digital insights manager at Adobe.
Hotels and air fares aren’t the only travel items that are more expensive.
The national average price for a gallon of regular gasoline today stands at $ 3.13, a seven-year high and a 44% increase from a year ago.
The most extreme example? Rental car prices, which have not only soared 110% from a year ago to record levels, but are 70% higher than even the pre-pandemic prices, according to the May Conumer Price Index.
The increase in pricing is connected to the supply of autos. To raise enough cash to survive the downturn, rental car companies sold off about a third of their fleets, and they’ve been unable to purchase the replacement vehicles this year due to a chip shortage that’s choking off new car production. Significantly smaller fleets and a rebound in demand means significantly higher prices.
Unlike the rental car companies, hotels and airlines have restored most of the capacity they shut down during the pandemic.
But bringing back capacity has been somewhat constrained by staffing difficulties. Even airlines, which pay far above the wages paid in lodging, are struggling with staffing shortages at some of their suppliers. That has forced some airlines, including American (AAL), the largest, to cut back on flights they had planned to fly this summer, adding to the upward pressure on prices.

Author: Chris Isidore, CNN Business
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Heart attack: The savoury-tasting juice that protects against heart attack risk factors

Heart attack: The savoury-tasting juice that protects against heart attack risk factors

A heart attack is a serious medical emergency whereby the supply of blood to the heart is suddenly blocked, usually by a build-up of cholesterol. Cholesterol is a waxy substance that clogs up your arteries, starving your heart of the blood it needs to function. High blood pressure can also promote cholesterol build-up and contribute to heart attack risk.

The researchers found that systolic blood pressure lowered from an average of 141.2 to 137.0 mmHg, and diastolic blood pressure lowered from an average of 83.3 to 80.9 mmHg.

What do these numbers mean?

Blood pressure is recorded with two numbers. The systolic pressure (higher number) is the force at which your heart pumps blood around your body.

The diastolic pressure (lower number) is the resistance to the blood flow in the blood vessels.

They’re both measured in millimetres of mercury (mmHg).

“To the best of our knowledge, the current study is the first to investigate the effects of tomato or tomato product intake on cardiovascular disease risk markers over the course of a year and over a wide age range,” the authors wrote.

Heart attack – symptoms to be aware of

Symptoms of a heart attack can include:

  • Chest pain – a sensation of pressure, tightness or squeezing in the centre of your chest
  • Pain in other parts of the body – it can feel as if the pain is travelling from your chest to your arms (usually the left arm is affected, but it can affect both arms), jaw, neck, back and tummy (abdomen)
  • Feeling lightheaded or dizzy
  • Sweating
  • Shortness of breath
  • Feeling sick (nausea) or being sick (vomiting)
  • An overwhelming sense of anxiety (similar to having a panic attack)
  • coughing or wheezing.

“Although the chest pain is often severe, some people may only experience minor pain, similar to indigestion,” notes the NHS.

“In some cases, there may not be any chest pain at all, especially in women, older people, and people who have diabetes.”

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This post originally appeared on Daily Express :: Health Feed
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Risk Factors for Late Seizure Relapse After Epilepsy Surgery

Risk Factors for Late Seizure Relapse After Epilepsy Surgery

Incomplete resection and very early epilepsy onset were among the chief predictors of late seizure relapse following epilepsy surgery, according to a new study on the factors most associated with seizure recurrence in drug-resistant epilepsy.

“As our study analyzed late seizure relapse, our results are not applicable for short‐term seizure control. Vice versa, results for short‐term outcomes should not be transferred to long‐term outcomes,” Stephan Petrik of the Epilepsy Center at the University of Freiburg (Germany) and colleagues wrote. The study was published in the May 2021 issue of Epilepsia.

To assess the variables that increase risk of late seizure recurrence following surgery, the researchers retrospectively studied the medical records of patients who underwent resective epilepsy surgery at the University Hospital Freiburg (Germany) between 1999 and 2015. Of the 1,278 initial patients, a group of 99 participants (7.7%) with seizure relapses after at least 2 years of complete seizure freedom were matched with controls experiencing long-term seizure freedom. The two groups had similar mean durations of epilepsy from onset to surgery: 13.9 years in the relapse group and 13.0 years in the control group.

The mean follow-up was 9.7 years (standard deviation, 4.0; range, 2.9-18.5) in the relapse group and 8.2 years (SD, 3.5; range, 2.2-18.3) in the control group. The mean time to late seizure recurrence was 56.6 months, and two-thirds of patients relapsed in the 5 years after surgery. Twenty of the relapse patients only experienced a single seizure, and 41% of the patients who reported more than one seizure had a frequency of less than one per month.

The type of resection had no discernible impact on outcomes, although anterior temporal lobe resection did trend toward being associated with recurrence (odds ratio, 2.7; 95% confidence interval, 0.93-8.89; P = .06). Incomplete resection was significantly associated with late relapse but did not seem to affect timing: the mean duration of seizure freedom was 56.5 months with complete resection and 58.5 months with incomplete resection (P = .62). Additional preoperative PET scans were performed on 45% of patients in the relapse group, compared with 29% in the control group.

After multivariate analysis, predictors for late relapse included incomplete resection (OR, 3.81; 95% CI, 1.79-8.53; P < .001); the existence of additional, potentially epileptogenic lesions in the contralateral hemisphere on presurgical MRI (OR, 3.36; 95% CI, 1.18-10.62; P = .03); epilepsy onset during the first year of life (OR, 4.24; 95% CI, 1.4-15.89; P = .02); and preoperative PET scans being performed (OR, 2.47; 95% CI, 1.25-4.97; P = .01). Though use of preoperative and postoperative antiepileptic drugs (AEDs) was higher in the relapse group, along with complete withdrawal being more common in the control group (68%, compared with 51%), neither was deemed significant in multivariate analysis.

What to Do About Seizure Relapse Risk Factors

“This is one of the best analyses of the factors that contribute to late seizure relapse,” Gregory K. Bergey, MD, director of the Johns Hopkins Epilepsy Center in Baltimore, said in an interview. “Am I surprised by their results? Not necessarily.”

What did jump out, he said, was AED use not being a predictor of recurrence, as well as all the patients with late relapse having lesional epilepsy. “As they point out, you can have relapse with nonlesional epilepsy, but very often it happens in the first year or 2. If someone is 2 years out and doesn’t have a lesion, they’re probably more likely to remain seizure free.”

Despite the researchers’ comprehensive review of risk factors, the question remains: What to do with this information?

“They’ve done a very good job of identifying that 7.7% of 1,200 who are at risk of a late relapse,” he said. “Now, take those patients with high-risk factors and launch a trial where you keep medicines the same or do something that would alter that outcome.”

“The problem is,” he added, “that’s a 10-year study. It’s easy for me to sit here and call for one of those. But still, as valuable as this was, it’s a retrospective study. Now you have to say, what are the implications of this? What can we do in the prospective fashion?”

The authors acknowledged their study’s other limitations, including a lack of information on the reasons for an incomplete resection, a notable decrease in follow-up visits more than 5 years after surgery, and potential selection bias. They added, however, that “matching by age at surgery, gender, and time to relapse/last follow‐up” should have helped reduce any significant bias.

No potential conflicts of interest were disclosed.

This article originally appeared on MDedge.com, part of the Medscape Professional Network.

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This post originally appeared on Medscape Medical News Headlines

Covid: Four factors that increase your risk of prolonged illness revealed in new data

Covid: Four factors that increase your risk of prolonged illness revealed in new data
Millions of contributors to the Zoe Covid Study app have shown that up to one in 20 people who catch coronavirus suffer from long Covid. Here are the symptoms, longevity and risk factors. The analysis of the ongoing research has identified six commonly reported symptoms of long Covid, which are:

  1. Fatigue
  2. Shortness of breath
  3. Headaches
  4. Loss of smell
  5. Loss of taste
  6. Chest pain

Zoning in on a sub-section of 4,000 app users, who all tested positive for Covid with a PCR test, two groups were identified.

The first group experienced persistent respiratory symptoms, including coughing and shortness of breath.

The second group had “multi-system effects”, such as heart palpitations, pins and needles, and brain fog.

Long Covid seemingly lingers for more than eight weeks, with two percent of the users experiencing symptoms for 12 weeks or more.

“With millions of confirmed COVID-19 infections across the UK, this adds up to hundreds of thousands of people potentially affected with long COVID,” the researchers hypothesised.

READ MORE: Rhinoviruses are soaring in England due to easing of coronavirus restrictions – professor

The final – and fourth – element that contributes to the development of drawn-out symptoms is whether the person has had lots of different symptoms in the first week.

Although the exact cause behind long Covid is still under investigation, there have been scientific theories sprouting legs.

For instance, some experts suggest that long Covid is the result of the immune system struggling to return to normal following a Covid infection.

Meanwhile, studies have demonstrated that some long Covid sufferers have mild damage to their organs and tissues after catching the virus.

You may be referred to one of the new NHS long Covid clinics if you’ve been experiencing side effects for longer than 12 weeks.

There are more than 60 clinics across the UK full of doctors, nurses, physiotherapists and occupational therapists.

Researchers from the University of Birmingham are currently investigating the effectiveness of targeted therapies for the condition.

The aim is that further information will be brought to light about prevention and successful treatment of long Covid.

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This post originally appeared on Daily Express :: Health Feed
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Diabetes type 2: Doctor identifies two risk factors for diabetics to develop dementia

Author:
This post originally appeared on Daily Express :: Health Feed

Diabetes type 2: Doctor identifies two risk factors for diabetics to develop dementia

Speaking exclusively to the Express.co.uk is Dr Eszter Vamos – the lead researcher from Imperial College London. “It’s never too late, or early, to reduce your risk of dementia,” she said. “Our research conducted among people with diabetes highlights that while it is never too late to take action, mid-life (usually defined as 45 to 64 years) is very important to help reduce the risk of dementia.” Having diabetes is already a risk factor for dementia, but Dr Vamos found that higher blood pressure and cholesterol levels increased the risk further.

The findings demonstrated that changes in blood pressure differed between those who did and didn’t develop dementia.

People with higher blood pressure readings earlier on in life were more likely to develop dementia.

In addition, blood sugar and cholesterol levels were also found to be generally higher across the entire 20-year period among people with type 2 diabetes who developed dementia compared to those who didn’t.

Dr Vamos commented on the data: “Our results emphasise the importance of carefully managing cardiometabolic factors such as blood pressure, cholesterol and glucose levels early on for people with type 2 diabetes.

“Regular check-ups and early comprehensive management of potential risk factors might help reduce dementia risk.”

Dr Vamos continued: “While this study can’t confirm causal associations, these results show that blood pressure and other cardiometabolic factors could be contributing to dementia development up to two decades before diagnosis.”

Another interesting finding was that 11 to 19 years before their dementia diagnosis, blood pressure readings steeply declined.

In addition, the diabetic group who later developed dementia had a decline in body weight up to 11 years prior to their diagnosis.

When questioned why this would be, Dr Vamos explained to Express.co.uk why this would be.

“Previous research has shown that weight and blood pressure often reduce during the early stages of dementia, years before its diagnosis,” Dr Vamos said.

“These changes might be the result of dementia itself, due to gradual changes in behaviour including diet, reduced calorie intake, and physical activity.”

Dr Vamos’s study results highlight the importance of keeping blood pressure and cholesterol levels under control in order to mitigate the risk of dementia.

Director of Research at Diabetes UK, Dr Elizabeth Robertson, said that “for the first time, researchers have uncovered a pattern of changes in people with type 2 diabetes that are associated with dementia”.

Becoming aware of these risk factors – high blood pressure and high cholesterol – is “vital in given people with type 2 diabetes the best possible care”.

Dementia UK advises everybody – whether or not you have diabetes – to eat healthy, keep active, reduce alcohol intake and to not smoke.

Leading a healthy lifestyle is the best preventative tool you have to reduce your risk of disease.

Dr Vamos presented her findings to the scientific community on Tuesday, April 27 2021.

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