Tag Archives: late

Heart attack symptoms: ‘Brief’ symptoms that people often ‘ignore’ before it’s too late

BELIEVE it or not, heart attacks can be predicted as your body sends out signals from days before a heart attack occurs. Harvard Health warns that about half of the cases are mistaken for minor problems and can increase your risk of dying from coronary artery disease.

Read more here Daily Express :: Health Feed

How Prince Charles honoured beloved late great-uncle Lord Mountbatten on his wedding day

It is well known that Prince Charles shared a close relationship with his great-uncle Lord Louis Mountbatten, 1st Earl Mountbatten of Burma. Mountbatten, who was a maternal uncle of Charles’s father Prince Philip, Duke of Edinburgh, and second cousin once removed of his mother Queen Elizabeth II, served as a mentor and a close confidante for the heir apparent.

Mountbatten was assassinated by the IRA in 1979, two years before the Prince of Wales wed Lady Diana Spencer. To honour his late great-uncle at his wedding, Charles requested his bride to include the Mountbatten rose in her bridal bouquet. Florist David Longman, a member of the Worshipful Company of Gardeners who created the floral arrangements for the 1981 wedding, shared the anecdote in a new Royal documentary “The Wedding of the Century” that premieres on BritBox on Thursday.

“The Prince made one request and that was a Mountbatten rose in memory of his uncle, who he was very attached to. He particularly wanted it. There was only one grower. It’s not really a florists’ rose – it’s a garden rose. And it was only one colour because it’s a golden rose there in the centre of the bouquet,” he revealed.

The florist also recalled the intricate process of preparing the bouquet for the iconic wedding, which was set to introduce the country to its new Princess of Wales and the future Queen consort.

“My conversations with Lady Diana were very similar to so many discussions I had with brides and what they wanted. I showed her the designs – we had many more designs and more intricate designs than I would show to a normal bride. We talked to the dressmaker beforehand. I had been to see the dressmaker,” Longman said.

Longman revealed that the wedding gown designers, Elizabeth Emanuel and David Emanuel were “very discreet” as they had to keep the design secret, and didn’t tell him very much about it. However, they gave him a patch of material so he could feel what it was going to be like. “And they showed me an outline sketch so I knew it was going to be a very voluminous dress,” he said.

Recalling the late Princess Diana, Longman said, “she was like any other bride, excited, intrigued, wanting guidance as to what she was to have, very normal, a very, very normal young bride. She chose this one, which was a long drop bouquet, lily of the valley, stephanotis, orchids.”

Longman, whose father had created the floral bouquets for both Queen Elizabeth II and her sister Princess Margaret’s weddings, revealed that Diana was “always charming, very easy to deal with,” and wasn’t “particularly demanding,” but had only one special request. The Princess had noticed in a picture from the wedding of her mother-in-law, the Queen, that the bride was the only one without a bouquet while posing with all the bridesmaids. This was because the Queen, then Princess Elizabeth, had asked for her bouquet to be put on the tomb of the Unknown Warrior.

Longman recalled, “Lady Diana had heard this story so she said: ‘Please can we have two bouquets?’ So, we had one that went straight onto the tomb and the other that was delivered to Buckingham Palace ready for the photographs.”

Princess Diana
29 July 1981: Lady Diana stands with Prince Charles of Wales at their wedding at St Paul Cathedral in London
Getty Images

Read more
This post originally posted here United Kingdom News

Will Prince Charles deny passing on late father Duke of Edinburgh’s title to brother Edward

Prince Charles is reportedly having second thoughts about passing the Duke of Edinburgh’s title to his younger brother Prince Edward.

The heir apparent to the British throne inherited the title upon the death of his father Prince Philip on April 9. It was expected that after he ascends to the throne and becomes the King of the United Kingdom, he would pass on his late father’s title to his youngest sibling, Prince Edward. It had been known for a long time that the late Prince Consort intended to bestow the title to his youngest child Prince Edward, who is currently Earl of Wessex, unlike his elder brothers Prince Charles and Prince Andrew, who are Duke of Cornwall and Duke of York respectively.

At the time of Edward’s wedding to Sophie Rhys-Jones in 1999, a statement by the palace had announced that they would be titled the Earl and Countess of Wessex. However, the statement also noted, “the Queen, The Duke of Edinburgh and the Prince of Wales have also agreed that the Prince Edward should be given the Dukedom of Edinburgh in due course, when the present title now held by the Prince Philip eventually reverts to the Crown.”

As revealed by the palace, the Duke of Edinburgh’s title will merge with the Crown when its holder Prince Charles takes over the throne. As the new monarch, he can then decide whether to bestow it on his brother or another member of the royal family, or hold it in abeyance for a time in the future.

According to a new report in The Sunday Times, the Prince of Wales is now thinking about changing the original decision about the title that he had taken with his parents. A friend of the 72-year-old was quoted as saying, “It is up to him what happens to the title. It will not go to Edward.”

Another source claimed, “Edinburgh won’t go to [the Wessexes] as far as the prince is concerned.”

A spokesperson for Prince Charles released a clarification on the matter, but shied away from confirming that the royal still plans to transfer his title to his younger brother. The statement to People magazine read, “All stories of this nature are speculation and no final decisions have been taken. It would be inappropriate and disrespectful to the Queen to comment on matters of accession and we will be maintaining our long-standing policy of not doing so.”

The Wessexes have themselves also commented on inheriting the title in the past, noting that the final decision lies with Prince Charles. While Countess Sophie revealed that her late father-in-law had asked them if they would consider taking on the title just two days after their engagement, her husband noted that his elder brother Prince Andrew could have been the first choice for it.

“It’s a very bittersweet role to take on because the only way the title can come to me is after both my parents have actually passed away. It has to go back to the Crown first. My father was very keen that the title should continue, but he didn’t quite move quickly enough with Andrew, so it was us who he eventually had the conversation with. It was a lovely idea; a lovely thought,” Edward said.

Prince Andrew was gifted the Duke of York title upon his wedding to Sarah Ferguson in 1986, which he still sustains despite quitting royal duties in 2019 due to public uproar over his alleged involvement with convicted sex offender Jeffrey Epstein.

Prince Philip Duke of Edinburgh
5 April 2002: Prince Andrew, Prince Charles, Prince Philip, Princess Anne and Prince Edward walk behind the coffin of the Queen Mother during a ceremonial procession in London
Pool

Yang and Garcia Form Late Alliance in Mayor’s Race, Drawing Adams’s Ire

The campaigns of Mr. Yang and Ms. Garcia both denied that Ms. Wiley had been invited to Saturday’s events.

Ms. Wiley declined to criticize the joint appearance of Ms. Garcia and Mr. Yang, even as she seemed to dismiss the possibility of doing something similar.

“Candidates gonna candidate,” she said on Saturday. “I’m going to talk to people.”

Ms. Wiley also received an endorsement on Saturday from Alessandra Biaggi, a prominent state senator, another sign of momentum for Ms. Wiley among progressive leaders. Ms. Biaggi had endorsed Scott M. Stringer, the city comptroller, but withdrew her support after he was accused of sexual misconduct.

Mr. Sharpton suggested that Mr. Adams’s strategy appeared to be centered on attracting as many Black and Latino voters as possible in places like the Bronx, Central Harlem and Central Brooklyn, and making inroads with moderate white voters. Public polls suggest that Mr. Adams has a clear advantage with Black voters, but Mr. Yang and Ms. Garcia are also competing for Latino and moderate white voters.

“He’ll get some moderate white voters because of his crime stand,” Mr. Sharpton said of Mr. Adams. “With this uptick in violence, he’s the one that’s taken the definitive stand in terms of public safety.”

The Yang-Garcia event did cost Ms. Garcia a ranked-choice vote from Jumaane Williams, the city’s public advocate. Mr. Williams had endorsed Ms. Wiley as his first choice and announced his secondary choices on Saturday, among them Mr. Adams.

Ms. Garcia’s alliance with Mr. Yang, he said, was enough to exclude her from his ballot. “As I’ve said previously, while I have concerns about multiple candidates, at this point I’m singularly most concerned about Andrew Yang for mayor,” he said.

Mr. Adams, for his part, seemed to be having fun on the campaign trail. At Orchard Beach in the Bronx, he appeared in swimming trunks, grinning and waving at beachgoers who called out greetings from the sand. Then Mr. Adams waded out into the water.

Reporting was contributed by Anne Barnard, Katie Glueck and Michael Gold.

Author: Emma G. Fitzsimmons and Jeffery C. Mays
This post originally appeared on NYT > Top Stories

Monitoring for potential tropical development late next week, development chances at 40%

June 12

7 a.m. update
The area we are monitoring in the Gulf now has a 40% chance of development over the next 5 days. It’s too early for specifics on exact impacts, but the moisture will gradually lift north. For now it’s just something we will be keeping an eye on.

June 11

9 a.m. update
The National Hurricane Center has tagged an area of disturbed weather over the Bay of Campeche with a 20% chance for tropical development over the next 5 days.

Slow development will be possible as this system lifts to the north to northwest. It is still too early to determine what impacts our region could see. Residents along the upper Texas coast should keep an eye on the tropics.

June 10

9 a.m. update
No imminent threat for tropical development over the next 5 days.

However, the Climate Prediction Center says conditions may become more favorable for tropical development in the western Gulf of Mexico late next week. Resident along the upper Texas coast should keep an eye on the tropics.

June 9

8 a.m. update
Formation chances with the disturbance in the southern Caribbean continues to be at a 10% chance over the next five days. However, residents along the upper Texas coast should keep up with the tropics. The Climate Prediction Center expects conditions to become more favorable for tropical development in the western Gulf of Mexico late next week.

June 8

6 p.m. update
Formation chances with the disturbance in the southern Caribbean continues to be at a 20% chance over the next five days. However, residents along the upper Texas coast should keep up with the tropics. The Climate Prediction Center says conditions may become more favorable for tropical development in the western Gulf of Mexico late next week.

2 p.m. update
Formation chance with the disturbance in the southern Caribbean has dropped to a 20% chance over the next five days.

10 a.m. update
Some gradual development will be possible with a tropical disturbance in the southern Caribbean over the next few days. Formation chance is just at 30% over the next 5 days, we’ll continue to monitor it.

Regardless of development, this system will produce heavy rainfall across northern Colombia and portions of Central America later this week and into the weekend.

June 7

Our tropical disturbance in the southern Caribbean remains at just a 20% chance of development over the next 5 days, we’ll continue to monitor it.

June 6

There’s a 20% (low) chance of tropical development over the next 5 days in an area just east of Central America in the southern Caribbean Sea. An area of low pressure could develop by the end of the week and may try to gradually strengthen as it moves northwest. We’ll continue to monitor this area.

June 5

No tropical development is expected in the tropical Atlantic in the next 5 days.

However, NOAA is giving us an early heads up with “high confidence” that one or more tropical systems may spin up in the western Caribbean Sea between June 9th and June 15th.

Why?
Because a large area of low pressure known as the “Central American Gyre” is expected to spin up, and these often will produce one or more smaller low pressure systems that can break off and develop into tropical depressions and storms. There’s no way to know exact details at this time and there’s certainly nothing to worry about right now, but we do want you to at least be casually aware of the possibility just in case.

June 4

No tropical development is expected in the tropical Atlantic in the next 5 days.

In the Eastern Pacific, Blanca has weakened to a post-tropical cyclone and is expected to weaken even further as it heads westward into a drier environment with increasing wind shear and cooler waters.

Just east of Blanca, an area of disturbed area is being monitored for potential tropical development. The formation chance is at 60% during the next 5 days. A tropical depression could form late this weekend or early next week while it moves slowly to the west-northwest well off the coast of Mexico.

June 3

No tropical development is expected in the next 5 days.

In the Eastern Pacific, Blanca is now a tropical depression and is expected to weaken even further as it heads westward into a drier environment with increasing wind shear and cooler waters.

June 2

No tropical development is expected in the next 5 days.

In the Eastern Pacific, Tropical Storm Blanca continues to move west away from Mexico. It should remain as a tropical storm through midweek but should weaken sometime on Thursday down to a tropical depression.

June 1

Today is the official start of the 2021 Atlantic Hurricane Season. No tropical development is expected in the next 5 days.

In the Eastern Pacific, Tropical Storm Blanca continues to move west away from Mexico. It should remain as a tropical storm through midweek but should weaken sometime on Thursday down to a tropical depression.

May 31

No tropical development is expected as the Atlantic hurricane season kicks off tomorrow.

However, in the Eastern Pacific Tropical Depression Two-E is expected to strengthen into a tropical storm within the next 24 hours as it drifts south of Mexico. This system is expected to remain below hurricane strength and eventually fall apart as it moves over cooler water.

A tropical wave is just west of Two-E and has a slim chance for tropical development during the next five days.

May 26

There are no areas of concern for development for the next 5 days in the Atlantic, Gulf or Caribbean.

May 24

Ana has dissipated and no tropical development is expected during the next five days.

May 23

11 p.m. update
Ana is now a post-tropical cyclone and should dissipate Monday as it moves northeast farther out into the Atlantic.

3 p.m. update
Ana has now been downgraded to a tropical depression with 35 mph winds. Ana is forecast to become a remnant low by tonight as it moves northeast out farther into the Atlantic.

12 p.m. update
Ana is barely holding on as a tropical cyclone in the Atlantic as it churns around 425 miles northeast of Bermuda. Ana’s maximum sustained winds were around 40 mph Sunday morning and was moving northeast at approximately 14 mph. An increase in forward speed was expected in the next day or so. Tropical storm-force winds extended outward up to 35 miles and there are no impacts to land. Ana is expected to weaken and dissipate by Monday.

5 a.m. update
Still plenty of moisture in SE Texas from the disturbance that moved through early Saturday morning, with light rain expected in Houston and heavier rain to our southwest. Elsewhere, 340 miles to the northeast of Bermuda our first named storm, Ana, continues to gradually move northeast over open water. Ana will not make landfall anywhere, and will dissipate early next week.

May 22

11 p.m. update
The tropical disturbance that brought us our rain chance today continues to lift to the north.

Subtropical Storm Ana formed early Saturday and is now making its way northeast out to sea in the Atlantic. It is currently 270 miles northeast of Bermuda and is moving northeast at 9 mph. Ana currently has sustained wind speeds of 45 mph but is expected to weaken over the next 24 hours… eventually dissipating by Monday.

1 p.m. update
Our tropical disturbance responsible for bringing showers to SE Texas today continues to spin through the Hill Country. The moisture that it continues to pump into our area has produced widely scattered showers, especially west of I-45.

SubTropical Storm Ana, our first named storm of the season, is lifting away from Bermuda and poses no threat to land.

10 a.m. update
Subtropical storm Ana formed in the Atlantic Ocean early Saturday, according to the National Hurricane Center. Ana was located about 200 miles northeast of Bermuda Saturday morning with maximum sustained winds of 45 mph. The system was expected to continue its slow and erratic motion, and then dissipate in a few days, forecasters said.

Here in the Houston area, the Gulf tropical disturbance continues to weaken and move to the north-northwest. Outer rain bands will continue to impact the Houston area today. A wind advisory has been extended for the Bolivar Peninsula, coastal Jackson, Matagorda, Brazoria and Galveston Island until 4 p.m. Coastal flood advisories continue for Chambers, coastal Brazoria, Galveston and Harris counties until 7 a.m. Sunday.

7 a.m. update
The National Weather Service has issued flood warnings for several rivers and streams across the region as rain-swollen banks continue to be impacted by scattered showers today. Impacts from the disturbance continue to include locally heavy rainfall, breezy conditions along the coast, elevated tides and marine hazards. The center of the system should push northwest throughout the day. The highest rain chances through noon should be along and west of the Brazos River. Those rain chances will expand across the area later today.

5 a.m. update
The disturbance in the Gulf moved inland near Port Lavaca, and the National Hurricane Center doesn’t expect any more development. Locally, our impacts remain unchanged from prior updates, scattered showers and storms with breezy 30-40mph wind gusts possible, especially along the coast. The NWS has issued a Coastal Flood Warning through 7 a.m. for our coastal communities.

In a much different part of the world, northeast of Bermuda, we now have our first named storm: Subtropical Storm Ana has formed. This storm will have no direct impact on land, and is only notable for being our first named storm of the year, arriving before hurricane season officially begins.

May 21

1 p.m. update
The NHC is now giving the disturbance in the Gulf a 30% chance of development (becoming a Tropical Depression or Tropical Storm).

The impacts in our area will be minor regardless of development. We can expect scattered showers and storms along with wind gusts over 30 mph overnight and through Saturday, with rain tapering off from east to west on Sunday.

Still, if it makes landfall in Texas at tropical depression or storm strength, it’ll be the first in recorded history to do so before June 1, the customary start of the Atlantic hurricane season.

1 p.m. update
A large area of thunderstorms in the western Gulf is drifting northwest towards the Texas coast.

Conditions are slightly favorable for development and the National Hurricane Center is giving it a 60% chance. Whether it develops or not, it’ll give us at least scattered, heavy downpours overnight and through the day on Saturday.

High rain rates along with the slow movement of the storms means some flooding will be possible. Gusty winds and coastal flooding may also be an issue near the coast.

May 20, 2021

According to the latest NOAA outlook, the 2021 Atlantic hurricane season will be busier than normal, but it’s unlikely to be as crazy as 2020’s record-shattering year.

They’re expecting 13-20 tropical storms, 6-10 hurricanes, and 3-5 major hurricanes.

Hurricane season runs from June 1 through November 30, although storms can form before and after those dates.

During hurricane season, ABC13 meteorologists will provide daily tropical weather updates on this page.

RADAR MAPS:
Southeast Texas
Houston
Harris County

Galveston County
Montgomery/Walker/San Jacinto/Polk/Grimes Counties
Fort Bend/Wharton/Colorado Counties
Brazoria/Matagorda Counties

During hurricane season, remain prepared and make sure you download our ABC13 Houston app!

Copyright © 2021 KTRK-TV. All Rights Reserved.

Author: Travis Herzog

This post originally appeared on ABC13 RSS Feed

Coral reefs are dying, but it’s not too late to save them

The global outlook for coral doesn’t look good. The reef-building animals, which create the living architecture for some of the most diverse ecosystems on the planet, are acutely vulnerable to climate change, and are experiencing heavy losses already. Without dramatic emissions reductions in the coming decade, their future is increasingly dire.

But that doesn’t mean that the end is inevitable. As two recent studies make clear, humans can still help reefs hang on in a warming ocean.

“We really do think of our story as good news,” says Mary Donovan, a professor of conservation science at Arizona State University, and a lead author on one of the studies. “The impacts of climate change on coral reefs are quite overwhelming. So to be able to uncover other effects [on reefs] puts it in the hands of everybody—we’re saying, human impacts are making things worse, and also, we can actually improve conditions.”

The primary climactic threat to coral is called bleaching. Coral polyps, the animals that build the reef structure itself, live in a symbiotic partnership with colorful algae, which provide food. But in marine heat waves, the polyps kick out their algae partners, leaving the reef bone-white. A healthy reef can recover from the blow, but if conditions get bad enough, it will die entirely, and the entire structure will begin to crumble.

According to Donovan’s research, published last week in Science, those bleaching events could be exacerbated by two key local trends: pollution and overfishing. And that means that local restoration efforts could help reefs survive the majority of heat waves.

The reefs that fared the worst after bleaching events tended to have an overabundance of seaweed, which flourishes in water polluted with nutrient-rich runoff, and which would normally be kept in check by herbivorous reef fish. That seaweed releases chemicals that directly stress the reef.

“When it gets really hot, coral gets really stressed,” Donovan says, “and if you’ve got anything else stressing them out, that’s really bad.”

More surprisingly, bleaching was also associated with an overabundance of sea urchins. Under normal circumstances, those urchins would feed on the seaweed. But when their predators are overfished, the urchin population can also explode.

“There’s kind of this Goldilocks zone, where at very extreme abundances, they’re doing more harm than good,” Donovan says. “There’s nothing left to eat, there’s so many of them, they’ve chowed away at the bottom, so they just keep going. They’ve got these really strong teeth, for lack of a better word, and they start eroding away the reef itself.”

Humans can also help undo that damage.

For one thing, local fishery managers might protect the species—parrotfish, surgeonfish, unicorn fish—that go after seaweed. That’s already happening in Hawai’i’s Kahekili Marine Reserve, Donavan says. But, she stressed, “in many of the places where coral reefs exist, people living near the reefs and the reefs themselves are highly connected. Often the society is relying very heavily on the reef for subsistence. It’s important not to paint fishing as a bad thing. It’s a matter of survival for a lot of people all over the world.”

[Related: How divers found 4 new coral species, hidden in plain sight]

More obviously, reducing nutrient pollution (often by cleaning up sewage), could both help reefs and human health.

Other research, published in the Proceedings of the National Academy of Sciences, suggests that humans might also be able to nudge the evolution of corals towards bleach-resistance.

In the Caribbean and Great Barrier Reef, conservationists have already begun planting tens of thousands of corals from nurseries. Ideally, they would select the corals that appeared to survive heat waves without bleaching. But that requires bleach-resistance to be a trait that survives when a coral is moved. It’s possible those corals were resilient because of their habitat, or would be so stressed by the move that they’d be newly vulnerable.

To test how bleach resistance travels, a team in Hawai’i took pieces from corals that had weathered back-to-back heat waves, and moved them around the reef.

It took several months for them to become settled in their new environments, but after that, both appeared to keep their heat-resistant properties in lab tests. And because a coral is home to thousands of genetically identical organisms, it’s likely that as the transplant grows, it will make the entire section of reef more heat tolerant.

Taken together, the two studies outline a multifaceted approach to saving coral.

“Many of the people who are most impacted by the decline of corals are not the ones in control of climate policies,” Donovan says. And headlines about massive bleaching events, like on the Great Barrier Reef in 2015 “leave a lot of people discouraged. So our work clearly sends the message that action on all levels is necessary in ensuring the future of corals.”

Philip Kiefer

Author: Sara Chodosh
This post originally appeared on Science – Popular Science

Russia to reveal prototype of its digital ruble in late 2021 – Central Bank

The Central Bank of Russia will launch a prototype of the digital ruble, a new form of national currency, by as early as the end of the current year, the regulator has confirmed.

We have just released an advisory report along with the concept of the digital ruble,” First Deputy Governor Olga Skorobogatova told a working group of the State Duma Committee on the Financial Market.

The senior official also said that the regulator will develop the prototype platform by the end of the year, and is going to observe the market to plan the subsequent stages of the project.
Also on rt.com Digital currencies may challenge SWIFT global payment network, says Russian central bank
The concept of a national digital currency was unveiled by the Russian Central Bank in late 2020. The new form of money is expected to coexist with cash and non-cash rubles. Unlike virtual currencies such as bitcoin, the digital ruble is projected to pose minimal risk since it will be issued by the state monetary regulator, and will be backed by traditional money.

The latest survey, carried out by the Skolkovo Center for Research in Financial Technologies and Digital Economy, showed that roughly half of those polled supported the idea of the digital ruble, while nearly 40% of respondents were against it.

For more stories on economy & finance visit RT’s business section

Author: RT
This post originally appeared on RT Business News

Risk Factors for Late Seizure Relapse After Epilepsy Surgery

Incomplete resection and very early epilepsy onset were among the chief predictors of late seizure relapse following epilepsy surgery, according to a new study on the factors most associated with seizure recurrence in drug-resistant epilepsy.

“As our study analyzed late seizure relapse, our results are not applicable for short‐term seizure control. Vice versa, results for short‐term outcomes should not be transferred to long‐term outcomes,” Stephan Petrik of the Epilepsy Center at the University of Freiburg (Germany) and colleagues wrote. The study was published in the May 2021 issue of Epilepsia.

To assess the variables that increase risk of late seizure recurrence following surgery, the researchers retrospectively studied the medical records of patients who underwent resective epilepsy surgery at the University Hospital Freiburg (Germany) between 1999 and 2015. Of the 1,278 initial patients, a group of 99 participants (7.7%) with seizure relapses after at least 2 years of complete seizure freedom were matched with controls experiencing long-term seizure freedom. The two groups had similar mean durations of epilepsy from onset to surgery: 13.9 years in the relapse group and 13.0 years in the control group.

The mean follow-up was 9.7 years (standard deviation, 4.0; range, 2.9-18.5) in the relapse group and 8.2 years (SD, 3.5; range, 2.2-18.3) in the control group. The mean time to late seizure recurrence was 56.6 months, and two-thirds of patients relapsed in the 5 years after surgery. Twenty of the relapse patients only experienced a single seizure, and 41% of the patients who reported more than one seizure had a frequency of less than one per month.

The type of resection had no discernible impact on outcomes, although anterior temporal lobe resection did trend toward being associated with recurrence (odds ratio, 2.7; 95% confidence interval, 0.93-8.89; P = .06). Incomplete resection was significantly associated with late relapse but did not seem to affect timing: the mean duration of seizure freedom was 56.5 months with complete resection and 58.5 months with incomplete resection (P = .62). Additional preoperative PET scans were performed on 45% of patients in the relapse group, compared with 29% in the control group.

After multivariate analysis, predictors for late relapse included incomplete resection (OR, 3.81; 95% CI, 1.79-8.53; P < .001); the existence of additional, potentially epileptogenic lesions in the contralateral hemisphere on presurgical MRI (OR, 3.36; 95% CI, 1.18-10.62; P = .03); epilepsy onset during the first year of life (OR, 4.24; 95% CI, 1.4-15.89; P = .02); and preoperative PET scans being performed (OR, 2.47; 95% CI, 1.25-4.97; P = .01). Though use of preoperative and postoperative antiepileptic drugs (AEDs) was higher in the relapse group, along with complete withdrawal being more common in the control group (68%, compared with 51%), neither was deemed significant in multivariate analysis.

What to Do About Seizure Relapse Risk Factors

“This is one of the best analyses of the factors that contribute to late seizure relapse,” Gregory K. Bergey, MD, director of the Johns Hopkins Epilepsy Center in Baltimore, said in an interview. “Am I surprised by their results? Not necessarily.”

What did jump out, he said, was AED use not being a predictor of recurrence, as well as all the patients with late relapse having lesional epilepsy. “As they point out, you can have relapse with nonlesional epilepsy, but very often it happens in the first year or 2. If someone is 2 years out and doesn’t have a lesion, they’re probably more likely to remain seizure free.”

Despite the researchers’ comprehensive review of risk factors, the question remains: What to do with this information?

“They’ve done a very good job of identifying that 7.7% of 1,200 who are at risk of a late relapse,” he said. “Now, take those patients with high-risk factors and launch a trial where you keep medicines the same or do something that would alter that outcome.”

“The problem is,” he added, “that’s a 10-year study. It’s easy for me to sit here and call for one of those. But still, as valuable as this was, it’s a retrospective study. Now you have to say, what are the implications of this? What can we do in the prospective fashion?”

The authors acknowledged their study’s other limitations, including a lack of information on the reasons for an incomplete resection, a notable decrease in follow-up visits more than 5 years after surgery, and potential selection bias. They added, however, that “matching by age at surgery, gender, and time to relapse/last follow‐up” should have helped reduce any significant bias.

No potential conflicts of interest were disclosed.

This article originally appeared on MDedge.com, part of the Medscape Professional Network.

Author:
This post originally appeared on Medscape Medical News Headlines

Nintendo hints at PS5-style stock shortages for Switch: Buy now before it's too late

There’s some potentially bad news for Switch customers this year, as Nintendo hints at stock shortages.

Nintendo Switch consoles were hard to come by during the first lockdown back in 2020, as demand hit new heights following the release of Animal Crossing.

Nintendo also ran into production issues, as semiconductor materials became increasingly difficult to come by.

After recovering in time for Christmas, Nintendo president Shuntaro Furukawa has admitted that future production plans are uncertain.

“Due to the global shortage of semiconductor materials, we are not able to produce all the products we want to,” Furukawa said (via VGC).

“We are doing everything we can, but there is an increasing sense of uncertainty about production plans. Our earnings forecast is based on the assumption that we will be able to secure parts and materials, and if the situation changes, we would like to respond by revising it.”

While there’s a good chance things could improve on the production front, it might be worth securing a Nintendo Switch console sooner rather than later.

This is especially true if you’re planning on buying one as a gift for an upcoming birthday or Christmas.

The production issues could also have a knock-on effect for the release of the rumoured Nintendo Switch Pro console.

Rumours of a new and improved Nintendo Switch have been doing the rounds for a while now, although Nintendo is yet to make any concrete announcement.

Nintendo’s response to the PS5 and Xbox Series X, the Switch Pro will allegedly support 4K visuals while offering improved performance.

In handheld mode, the new Nintendo Switch Pro will allegedly have a bigger display with an improved resolution.

Previous rumours have suggested it will launch in 2021, although this seems unlikely based on the latest comments made by Nintendo.

The only bad news about the new Nintendo Switch Pro is that it will reportedly have one or two exclusive games.

That’s according to an industry insider, who said that third-party developers will be especially keen to take advantage of the new technology.

“There will be some select exclusives, especially from third-party partners,” reads a Resetera post. “May not be a big number of them, but I know of at least one.”

Previous Nintendo upgrades have done something similar. Xenoblade Chronicles 3D and Fire Emblem Warriors were both exclusive to the New Nintendo 3DS, for example.

Author:
This post originally appeared on Daily Express :: Gaming Feed

Tom Jones says late wife’s criticism was ‘always right’ amid warning: ‘Am I being honest?’

“She was always right,” he added while speaking on Today FM with Feral D’Arcy.

The 80-year-old trusted Linda’s opinion above all others, as he sometimes even questioned his own intuition when it came to making hits.

He continued: “She was right, so I use to play things to her and say, ‘Am I coming through here? Am I loud and clear? Am I being honest?’

“She would say, ‘I love that, or I don’t know why you’re doing that one’. You know like that. 

Author:
This post originally appeared on Daily Express :: Celebrity News Feed