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Knights Templar unmasked as ‘origin’ to secret society’s Holy Grail link pinpointed

Knights Templar unmasked as 'origin' to secret society's Holy Grail link pinpointed

The famous Catholic military order is said to have boasted numbers of up to 20,000 members at its peak and was active for almost 200 years until its sudden demise. Between the 12th and 13th century the Templars were among the most skilled fighting units of the Crusade period and managed large Christian economic organisations across Europe and the Middle East. Their sudden reduction in power inspired the rise of legends and has seen them at the centre of intense research ever since, especially in regards to the Holy Grail.

And historian Daniel Jones detailed what he believes to be the catalyst to their mystique during an appearance on Dan Snow’s History Hit.

He said: “A little bit of it comes from their origin – the Temple Mount – which is what they are named after.

“There is a great mystery of the Christian faith and it all comes from the Temple Mount.

“It’s partly that, but I think it’s much more – the nature of their fall, the grotesque black propaganda that was levelled against them and their enormous wealth. 

“The unaccountability of the organisation with the combination of the military, spiritual and financial all rolled together make this a perfect organisation to attach to conspiracy.

“But I think the nature of their fall [was also vital] – the fact they were brought down so quickly, devastatingly and in such a short space of time.”

But Mr Jones also detailed a second reason why the Templars’ raised suspicions.

He added: “They then appeared to disappear and people think ‘no this can’t have happened’ and the ferocity that the French pursued them must mean they had something more than wealth.

“It is all total speculation but you can see why it is alluring. My normal response is ‘do you remember the Lehman Brothers?’ They vanished in 2008.

READ MORE: Knights Templar: Tunnel found near Jerusalem used to smuggle items ‘out of Holy Land’

But Mr Jones explained why the gaps in their history may have added fuel to the fire of such claims.

He continued: “There’s lots of stuff we don’t know about them and they were legends in their own lifetime – in the King Arthur story they were guardians of the grail.

“The idea of the grail and the Holy Grail is something that has a mystique of its own – mixed with the Templars and you have this incredible concoction of myth and magic.

“This is not just in the 20th and 21st century, it is as much a part of the history of the Templars as the Templars themselves.”

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This post originally posted here Daily Express :: World Feed

More Data Link Unmanaged Diabetes, High Glucose to Severe COVID-19

More Data Link Unmanaged Diabetes, High Glucose to Severe COVID-19

Editor’s note: Find the latest COVID-19 news and guidance in Medscape’s Coronavirus Resource Center.

Unmanaged diabetes and high blood glucose levels are linked to more severe COVID-19 and worse rates of recovery, according to results of a retrospective study.

Patients not managing their diabetes with medication had more severe COVID-19 and length of hospitalization, compared with those who were taking medication, investigator Sudip Bajpeyi, PhD, said at the annual scientific sessions of the American Diabetes Association.

In addition, patients with higher blood glucose levels had more severe COVID-19 and longer hospital stays.

Those findings underscore the need to assess, monitor, and control blood glucose, especially in vulnerable populations, said Bajpeyi, director of the Metabolic, Nutrition, and Exercise Research Laboratory in the University of Texas, El Paso, who added that nearly 90% of the study subjects were Hispanic.

“As public health decisions are made, we think fasting blood glucose should be considered in the treatment of hospitalized COVID-19 patients,” he said in a press conference.

Links Between Diabetes and COVID-19

There are now many reports in medical literature that link diabetes to increased risk of COVID-19 severity, according to Ali Mossayebi, a master’s student who worked on the study. However, there are fewer studies that have looked specifically at the implications of poor diabetes management or acute glycemic control, the investigators said.

It’s known that poorly controlled diabetes can have severe health consequences, including higher risks for life-threatening comorbidities, they added.

Their retrospective study focused on medical records from 364 patients with COVID-19 admitted to a medical center in El Paso. Their mean age was 60 years, and their mean body mass index was 30.3 kg/m2; 87% were Hispanic.

Acute glycemic control was assessed by fasting blood glucose at the time of hospitalization, while chronic glycemic control was assessed by hemoglobin A1c, the investigators said. Severity of COVID-19 was measured with the Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA), which is based on the patient’s respiratory rate, blood pressure, and mental status.

Impact of Unmanaged Diabetes and High Blood Glucose

Severity of COVID-19 severity and length of hospital stay were significantly greater in patients with unmanaged diabetes, as compared with those who reported that they managed their diabetes with medication, Bajpeyi and coinvestigators found.

Among patients with unmanaged diabetes, the mean qSOFA score was 0.22, as compared with 0.44 for patients with managed diabetes. The mean length of hospital stay was 10.8 days for patients with unmanaged diabetes and 8.2 days for those with medication-managed diabetes, according to the abstract.

COVID-19 severity and hospital stay length were highest among patients with acute glycemia, the investigators further reported in an electronic poster that was part of the ADA meeting proceedings.

The mean qSOFA score was about 0.6 for patients with blood glucose levels of at least 126 mg/dL and A1c below 6.5%, and roughly 0.2 for those with normal blood glucose and normal A1c. Similarly, duration of hospital stay was significantly higher for patients with high blood glucose and A1c as compared with those with normal blood glucose and A1c.

Aggressive Treatment Needed

Findings of this study are in line with previous research showing that in-hospital hyperglycemia is a common and important marker of poor clinical outcome and mortality, with or without diabetes, according to Rodolfo J. Galindo, MD, FACE, medical chair of the hospital diabetes task force at Emory Healthcare System, Atlanta.

“These patients need aggressive treatment of hyperglycemia, regardless of the diagnosis of diabetes or A1c value,” said Galindo, who was not involved in the study. “They also need outpatient follow-up after discharge, because they may develop diabetes soon after.”

Follow-up within is important because roughly 30% of patients with stress hyperglycemia (increases in blood glucose during an acute illness) will develop diabetes within a year, according to Galindo.

“We do not know in COVID-10 patients if it is only 30%,” he said, “Our thinking in our group is that it’s probably higher.”

Bajpeyi and coauthors reported no disclosures. Galindo reported disclosures related to Abbott Diabetes, Boehringer Ingelheim International, Eli Lilly, Novo Nordisk, Sanofi US, Valeritas, and Dexcom.

This article originally appeared on MDedge.com, part of the Medscape Professional Network.

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Anne Robinson says BBC would have cancelled her as Weakest Link host today 'Woke happened'

Anne Robinson says BBC would have cancelled her as Weakest Link host today 'Woke happened'

“I don’t want the contestants to have to have a box of Kleenex next to them.

However, she added to The Mirror: “With the Weakest Link I never spoke to contestants before the show.

“I was on the podium, with a stern face, to create the atmosphere.

“With Countdown, I have a chat with them, to stop them thinking it’s going to be very cruel.”

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This post originally appeared on Daily Express :: Celebrity News Feed

Do Anti-ApoA-1 Antibodies Link Fatty Liver Disease and CVD?

Do Anti-ApoA-1 Antibodies Link Fatty Liver Disease and CVD?

Anti-apolipoprotein A-1 (ApoA-1) antibodies are common in non-alcoholic fatty liver disease (NAFLD) and may not only drive its development but also underlie the link between NAFLD and cardiovascular disease, suggests a novel analysis.

Conducting a clinical analysis and a series of experiments, Sabrina Pagano, PhD, Diagnostic Department, Geneva University Hospital, Geneva, Switzerland, and colleagues looked for anti-ApoA-1 antibodies in patients with NAFLD and then examined their impact on hepatic cells and inflammatory markers.

They found that nearly half of 137 patients with NAFLD were seropositive, and that the antibodies were associated with increased lipid accumulation in the liver, altered triglyceride metabolism, and pro-inflammatory effects on liver cells.

“We hypothesize that anti-ApoA-1 IgG may be a potential driver in the development of NAFLD, and further studies are needed to support anti-ApoA-1 IgG as a possible link between NAFLD and cardiovascular disease,” Pagano said.

The research was presented May 31 at the European Atherosclerosis Society 2021 Virtual Congress.

Asked whether anti-ApoA-1 antibodies could represent a potential treatment target for NAFLD, Pagano told theheart.org | Medscape Cardiology that they have “already developed a peptide that is recognized by the antibodies in order to try to reverse the anti-ApoA-1 deleterious effect.”

While this was successful in vitro, “unfortunately we didn’t observe…the peptide reverse of these anti-ApoA-1 effects in mice, so…for the moment it’s a little early,” to say whether it represents a promising target.

Approached for comment, Maciej Banach, MD, PhD, full professor of cardiology, Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland, said that the results are “very interesting and encouraging.”

He said that his own global burden of disease analysis, which is set to be published soon, showed that the worldwide prevalence of NAFLD is 11%, “representing almost 900 million cases,” and a more than 33% increase in prevalence in the past 30 years.

Consequently, any “attempt to have effective, especially early, diagnosis and treatment,” is highly anticipated.

Banach said the findings from the experimental analyses are “very interesting and promising,” especially regarding the pro-inflammatory effects of anti-ApoA-1 antibodies.

However, he underlined that the clinical part, looking at antibody seropositivity in patients with NAFLD, was limited by the lack of a control group, and there was no indication as to what treatment the patients received, despite it being clear that many were obese.

Banach also believes that, taking into account the patient characteristics, it is likely that most of the patients had the more severe nonalcoholic steatohepatitis (NASH), and “it would be additionally useful to see the autoantibodies levels both in NASH and NAFLD.”

Nevertheless, the clinical utility of measuring anti-ApoA-1 antibodies is limited at this stage.

He said that the lack of “good, easy, and cheap diagnostic methods based on both laboratory and imaging data” for NAFLD means it would be difficult to determine whether assessing antibody seropositivity “might be indeed an added value.”

Independent Predictors

Pagano explained that anti-ApoA-1 antibodies, which target the major protein fraction of high-density lipoprotein cholesterol, are independent predictors of cardiovascular events in high-risk populations.

They are also independently associated with cardiovascular disease in the general population, as well as atherosclerotic plaque vulnerability in both mice and humans.

She said that ApoA-1 antibodies have a metabolic role in vivo, and have been shown in vitro to disrupt cholesterol metabolism, promoting foam cell formation.

Studies have also indicated they play a role in hepatic fibrosis, predicting the development of cirrhosis in individuals with chronic hepatitis C infection.

The team therefore set out to determine the presence of anti-ApoA-1 antibodies in individuals with NAFLD, defined here as fatty acid levels >5% of liver weight, as well as their effect on hepatic cells.

Working with colleagues at Magna Græcia University of Catanzaro, in Catanzaro, Italy, they obtained serum samples from 137 patients with NAFLD confirmed on ultrasound.

The patients had an average age of 49 years, and 48.9% were male. The median body mass index was 31.8 kg/m2. Cholesterol levels were typically in the intermediate range.

They found that 46% of the participants had anti-ApoA-1 IgG antibodies, “which is quite high when compared with the 15%-20% positivity that we retrieved from the general population,” Pagano said.

To explore the link between high anti-ApoA-1 antibodies and NAFLD, the team studied hepatic cells, treating them with anti-ApoA-1 IgG antibodies or control IgG antibodies, or leaving them untreated, for 24 hours.

This revealed that anti-ApoA-1 IgG antibodies were associated with a significant increase in liquid droplet content in hepatic cells compared with both cells treated with control IgG (P = .0008), and untreated cells (P = .0002).

Next, the team immunized apolipoprotein E knockout mice with anti-ApoA-1 or control IgG antibodies. After 16 weeks, they found there was a significant increase in liver lipid content in mice given anti-ApoA-1 antibodies vs those treated with controls (P = .03).

They then asked whether anti-ApoA-1 antibodies could affect triglyceride metabolism. They examined the expression of the transcription factor sterol regulatory element binding protein (SREBP) and regulation of the triglyceride and cholesterol pathways.

Treating hepatic cells again for 24 hours with anti-ApoA-1 IgG antibodies or control IgG antibodies, or leaving them untreated, showed that anti-ApoA-1 antibodies were associated with “dramatic”” increases in the active form of SREBP.

They also found that expression of two key enzymes in the triglyceride pathway, fatty acid synthetase and glycerol phosphate acyltransferase, was substantially decreased in the presence anti-ApoA-1 antibodies.

In both experiments, the untreated hepatic cells and those exposed to control IgG antibodies showed no significant changes.

“These results suggest that negative feedback…turns off these enzymes, probably due to the lipid overload that is found in the cells after 24 hours of anti-ApoA-1 treatment,” Pagano said.

Finally, the researchers observed that anti-ApoA-1, but not control antibodies, were associated with increases in inflammatory markers in liver cells.

Specifically, exposure to the antibodies was linked to an approximately 10-fold increase in interleukin (IL)-6 levels, as well as an approximate 25-fold increase in IL-8, and around a sevenfold increase in tumor necrosis factor-alpha.

Pagano suggested that the inflammatory effects are “probably mediated by binding anti-ApoA-1 antibodies to toll-like receptor 2, which has been previously described in macrophages.”

No funding was declared. The study authors have disclosed no relevant financial relationships.

European Atherosclerosis Society 2021 Virtual Congress: Abstract 704. Presented May 31, 2021.

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Pfizer vaccine side effects: Probable link to heart inflammation discovered – new study

Pfizer vaccine side effects: Probable link to heart inflammation discovered - new study

Adverse events are thoroughly reviewed and Pfizer meets regularly with the Vaccine Safety Department of the Israeli Ministry of Health to review data, it said.

Israel had held off making its 12 to 15-year-old population eligible for the vaccines, pending the Health Ministry report.

In parallel to publishing those findings, a ministry committee approved vaccinating the adolescents, a senior official said.

“The committee gave the green light for vaccinating 12- to 15-year-olds, and this will be possible as of next week,” Nachman Ash, Israel’s pandemic-response coordinator, told Radio 103 FM. “The efficacy of the vaccine outweighs the risk.”

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This post originally appeared on Daily Express :: Life and Style Feed
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Possible link between Tylenol during pregnancy and autism

Possible link between Tylenol during pregnancy and autism

(KXAN) — A new study out of Spain has uncovered what it calls a potential link between pregnant women using the drug acetaminophen — which many people know by the brand name Tylenol — and then their child developing autism or attention-deficit/hyperactivity disorder (ADHD).

Acetaminophen is also commonly known by the name paracetamol. It’s one of the most commonly used pain relievers in the world.

Researchers from the University of Barcelona studied health data from more than 73,000 mother-child pairs across Europe. They found that unborn children exposed to acetaminophen were 19% more likely to be on the autism spectrum and 21% more likely to show signs of ADHD.

“The most consistent pattern of results was observed for the association between prenatal acetaminophen exposure and ADHD symptoms,” the researchers wrote. They said the link was there in both boys and girls but was slightly stronger in boys.

The researchers did warn that this study is just a possible link. Readers should not take their findings as definitive proof.

“Our findings need to be interpreted with caution given the limitations of our study,” the researchers wrote.

Author: Wes Wilson
This post originally appeared on KXAN Austin

Royal Mail scam warning issued as 'genuine looking' email circulates – do not click link

Royal Mail scam warning issued as 'genuine looking' email circulates - do not click link
Customers of courier services such as Royal Mail, Hermes and DHL have been targeted by scams in recent months. Fake messages can be sent via text, email or even on social media.
It read: “There has been a rise in ‘Royal Mail’ delivery scams recently.

“Victims are receiving texts or emails claiming to be from Royal Mail stating a package requires a small payment for it to be delivered, or similar kinds of messages.”

It shared a post from Action Fraud which stated there have been more than 1,700 Royal Mail scam emails received in one week.

This gave details of the contents of a fake email which has been circulating.

DON’T MISS

The post stated: “Action Fraud received over 1,700 reports in one week about fake emails purporting to be from Royal Mail.

“The emails notify the recipients about missed parcel deliveries and provide links to reschedule them.

“The links in the emails lead to genuine-looking phishing websites that are designed to steal personal and financial information.”

Action Fraud stated banks and other official organisations will not ask for personal information over email or text.

Anyone who receives a suspicious looking message should report it to the Suspicious Email Reporting Service.

Some Britons have taken to social media to share scam messages they have received and warn others.

Posting on Twitter, one wrote: “Scam alert! Royal Mail does not send texts!”

She shared a picture of a message she had received asking for payment.

It said “Royal Mail: Your package has a £2.99 unpaid shipping fee. To pay this NOW please visit” and a link was attached.

Another shared a similar post of a text claiming to be from Royal Mail.

The fake message read: “Royal Mail: Your Package has been held and will not be delivered due to a £1.99 unpaid shipping fee.”

A third wrote: “I was so close to falling for a scam today where I clicked on a link from ‘Royal Mail’ @RoyalMail. I only got suspicious when it asked for my card details and then sort code.”

He shared a screenshot of the message which said: “Royal Mail: Your package has a £2 shipping fee, to pay this now visit [link].

“Package will be returned to the sender if unpaid.”

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This post originally appeared on Daily Express :: Life and Style Feed
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Price analysis 5/10: BTC, ETH, BNB, DOGE, XRP, ADA, DOT, BCH, LTC, LINK

The astronomical rally in Ether (ETH) is not showing any signs of slowing down. The bulls easily cleared the overhead hurdle at $ 4,000 today, which also pushed the biggest altcoin’s market dominance to over 19%. 

It is not only Ether that is witnessing sharp buying from traders. Litecoin (LTC) and Cardano (ADA) have also risen new all-time highs, suggesting a broad-based altcoin rally.

However, Bitcoin (BTC) seems to have lost its momentum as it continues to struggle near the $ 60,000 mark. That has pulled its market dominance to below 44% for the first time since July 2018.

Price analysis 5/10: BTC, ETH, BNB, DOGE, XRP, ADA, DOT, BCH, LTC, LINK
Daily cryptocurrency market performance. Source: Coin360

However, the recent underperformance of Bitcoin has not shaken the long-term bulls. Morgan Creek Capital Management founder and CEO Mark Yusko recently said in an interview with CNBC that Bitcoin will rival the “monetary value” of gold.

“If gold’s monetary value is $ 4 trillion, then digital gold should move up to that total,” Yusko added. That means Bitcoin will have to rise to $ 235,000 in the future to fulfill Yusko’s prediction.

Let’s analyze the charts of the top-10 cryptocurrencies to spot the critical support and resistance levels.