The famous Catholic military order is said to have boasted numbers of up to 20,000 members at its peak and was active for almost 200 years until its sudden demise. Between the 12th and 13th century the Templars were among the most skilled fighting units of the Crusade period and managed large Christian economic organisations across Europe and the Middle East. Their sudden reduction in power inspired the rise of legends and has seen them at the centre of intense research ever since, especially in regards to the Holy Grail.
And historian Daniel Jones detailed what he believes to be the catalyst to their mystique during an appearance on Dan Snow’s History Hit.
He said: “A little bit of it comes from their origin – the Temple Mount – which is what they are named after.
“There is a great mystery of the Christian faith and it all comes from the Temple Mount.
“It’s partly that, but I think it’s much more – the nature of their fall, the grotesque black propaganda that was levelled against them and their enormous wealth.
“The unaccountability of the organisation with the combination of the military, spiritual and financial all rolled together make this a perfect organisation to attach to conspiracy.
“But I think the nature of their fall [was also vital] – the fact they were brought down so quickly, devastatingly and in such a short space of time.”
But Mr Jones also detailed a second reason why the Templars’ raised suspicions.
He added: “They then appeared to disappear and people think ‘no this can’t have happened’ and the ferocity that the French pursued them must mean they had something more than wealth.
“It is all total speculation but you can see why it is alluring. My normal response is ‘do you remember the Lehman Brothers?’ They vanished in 2008.
READ MORE: Knights Templar: Tunnel found near Jerusalem used to smuggle items ‘out of Holy Land’
But Mr Jones explained why the gaps in their history may have added fuel to the fire of such claims.
He continued: “There’s lots of stuff we don’t know about them and they were legends in their own lifetime – in the King Arthur story they were guardians of the grail.
“The idea of the grail and the Holy Grail is something that has a mystique of its own – mixed with the Templars and you have this incredible concoction of myth and magic.
“This is not just in the 20th and 21st century, it is as much a part of the history of the Templars as the Templars themselves.”
Unmanaged diabetes and high blood glucose levels are linked to more severe COVID-19 and worse rates of recovery, according to results of a retrospective study.
Patients not managing their diabetes with medication had more severe COVID-19 and length of hospitalization, compared with those who were taking medication, investigator Sudip Bajpeyi, PhD, said at the annual scientific sessions of the American Diabetes Association.
In addition, patients with higher blood glucose levels had more severe COVID-19 and longer hospital stays.
Those findings underscore the need to assess, monitor, and control blood glucose, especially in vulnerable populations, said Bajpeyi, director of the Metabolic, Nutrition, and Exercise Research Laboratory in the University of Texas, El Paso, who added that nearly 90% of the study subjects were Hispanic.
“As public health decisions are made, we think fasting blood glucose should be considered in the treatment of hospitalized COVID-19 patients,” he said in a press conference.
Links Between Diabetes and COVID-19
There are now many reports in medical literature that link diabetes to increased risk of COVID-19 severity, according to Ali Mossayebi, a master’s student who worked on the study. However, there are fewer studies that have looked specifically at the implications of poor diabetes management or acute glycemic control, the investigators said.
It’s known that poorly controlled diabetes can have severe health consequences, including higher risks for life-threatening comorbidities, they added.
Their retrospective study focused on medical records from 364 patients with COVID-19 admitted to a medical center in El Paso. Their mean age was 60 years, and their mean body mass index was 30.3 kg/m2; 87% were Hispanic.
Acute glycemic control was assessed by fasting blood glucose at the time of hospitalization, while chronic glycemic control was assessed by hemoglobin A1c, the investigators said. Severity of COVID-19 was measured with the Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA), which is based on the patient’s respiratory rate, blood pressure, and mental status.
Impact of Unmanaged Diabetes and High Blood Glucose
Severity of COVID-19 severity and length of hospital stay were significantly greater in patients with unmanaged diabetes, as compared with those who reported that they managed their diabetes with medication, Bajpeyi and coinvestigators found.
Among patients with unmanaged diabetes, the mean qSOFA score was 0.22, as compared with 0.44 for patients with managed diabetes. The mean length of hospital stay was 10.8 days for patients with unmanaged diabetes and 8.2 days for those with medication-managed diabetes, according to the abstract.
COVID-19 severity and hospital stay length were highest among patients with acute glycemia, the investigators further reported in an electronic poster that was part of the ADA meeting proceedings.
The mean qSOFA score was about 0.6 for patients with blood glucose levels of at least 126 mg/dL and A1c below 6.5%, and roughly 0.2 for those with normal blood glucose and normal A1c. Similarly, duration of hospital stay was significantly higher for patients with high blood glucose and A1c as compared with those with normal blood glucose and A1c.
Aggressive Treatment Needed
Findings of this study are in line with previous research showing that in-hospital hyperglycemia is a common and important marker of poor clinical outcome and mortality, with or without diabetes, according to Rodolfo J. Galindo, MD, FACE, medical chair of the hospital diabetes task force at Emory Healthcare System, Atlanta.
“These patients need aggressive treatment of hyperglycemia, regardless of the diagnosis of diabetes or A1c value,” said Galindo, who was not involved in the study. “They also need outpatient follow-up after discharge, because they may develop diabetes soon after.”
Follow-up within is important because roughly 30% of patients with stress hyperglycemia (increases in blood glucose during an acute illness) will develop diabetes within a year, according to Galindo.
“We do not know in COVID-10 patients if it is only 30%,” he said, “Our thinking in our group is that it’s probably higher.”
Bajpeyi and coauthors reported no disclosures. Galindo reported disclosures related to Abbott Diabetes, Boehringer Ingelheim International, Eli Lilly, Novo Nordisk, Sanofi US, Valeritas, and Dexcom.
This article originally appeared on MDedge.com, part of the Medscape Professional Network.
Anti-apolipoprotein A-1 (ApoA-1) antibodies are common in non-alcoholic fatty liver disease (NAFLD) and may not only drive its development but also underlie the link between NAFLD and cardiovascular disease, suggests a novel analysis.
Conducting a clinical analysis and a series of experiments, Sabrina Pagano, PhD, Diagnostic Department, Geneva University Hospital, Geneva, Switzerland, and colleagues looked for anti-ApoA-1 antibodies in patients with NAFLD and then examined their impact on hepatic cells and inflammatory markers.
They found that nearly half of 137 patients with NAFLD were seropositive, and that the antibodies were associated with increased lipid accumulation in the liver, altered triglyceride metabolism, and pro-inflammatory effects on liver cells.
“We hypothesize that anti-ApoA-1 IgG may be a potential driver in the development of NAFLD, and further studies are needed to support anti-ApoA-1 IgG as a possible link between NAFLD and cardiovascular disease,” Pagano said.
The research was presented May 31 at the European Atherosclerosis Society 2021 Virtual Congress.
Asked whether anti-ApoA-1 antibodies could represent a potential treatment target for NAFLD, Pagano told theheart.org | Medscape Cardiology that they have “already developed a peptide that is recognized by the antibodies in order to try to reverse the anti-ApoA-1 deleterious effect.”
While this was successful in vitro, “unfortunately we didn’t observe…the peptide reverse of these anti-ApoA-1 effects in mice, so…for the moment it’s a little early,” to say whether it represents a promising target.
Approached for comment, Maciej Banach, MD, PhD, full professor of cardiology, Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland, said that the results are “very interesting and encouraging.”
He said that his own global burden of disease analysis, which is set to be published soon, showed that the worldwide prevalence of NAFLD is 11%, “representing almost 900 million cases,” and a more than 33% increase in prevalence in the past 30 years.
Consequently, any “attempt to have effective, especially early, diagnosis and treatment,” is highly anticipated.
Banach said the findings from the experimental analyses are “very interesting and promising,” especially regarding the pro-inflammatory effects of anti-ApoA-1 antibodies.
However, he underlined that the clinical part, looking at antibody seropositivity in patients with NAFLD, was limited by the lack of a control group, and there was no indication as to what treatment the patients received, despite it being clear that many were obese.
Banach also believes that, taking into account the patient characteristics, it is likely that most of the patients had the more severe nonalcoholic steatohepatitis (NASH), and “it would be additionally useful to see the autoantibodies levels both in NASH and NAFLD.”
Nevertheless, the clinical utility of measuring anti-ApoA-1 antibodies is limited at this stage.
He said that the lack of “good, easy, and cheap diagnostic methods based on both laboratory and imaging data” for NAFLD means it would be difficult to determine whether assessing antibody seropositivity “might be indeed an added value.”
Pagano explained that anti-ApoA-1 antibodies, which target the major protein fraction of high-density lipoprotein cholesterol, are independent predictors of cardiovascular events in high-risk populations.
They are also independently associated with cardiovascular disease in the general population, as well as atherosclerotic plaque vulnerability in both mice and humans.
She said that ApoA-1 antibodies have a metabolic role in vivo, and have been shown in vitro to disrupt cholesterol metabolism, promoting foam cell formation.
Studies have also indicated they play a role in hepatic fibrosis, predicting the development of cirrhosis in individuals with chronic hepatitis C infection.
The team therefore set out to determine the presence of anti-ApoA-1 antibodies in individuals with NAFLD, defined here as fatty acid levels >5% of liver weight, as well as their effect on hepatic cells.
Working with colleagues at Magna Græcia University of Catanzaro, in Catanzaro, Italy, they obtained serum samples from 137 patients with NAFLD confirmed on ultrasound.
The patients had an average age of 49 years, and 48.9% were male. The median body mass index was 31.8 kg/m2. Cholesterol levels were typically in the intermediate range.
They found that 46% of the participants had anti-ApoA-1 IgG antibodies, “which is quite high when compared with the 15%-20% positivity that we retrieved from the general population,” Pagano said.
To explore the link between high anti-ApoA-1 antibodies and NAFLD, the team studied hepatic cells, treating them with anti-ApoA-1 IgG antibodies or control IgG antibodies, or leaving them untreated, for 24 hours.
This revealed that anti-ApoA-1 IgG antibodies were associated with a significant increase in liquid droplet content in hepatic cells compared with both cells treated with control IgG (P = .0008), and untreated cells (P = .0002).
Next, the team immunized apolipoprotein E knockout mice with anti-ApoA-1 or control IgG antibodies. After 16 weeks, they found there was a significant increase in liver lipid content in mice given anti-ApoA-1 antibodies vs those treated with controls (P = .03).
They then asked whether anti-ApoA-1 antibodies could affect triglyceride metabolism. They examined the expression of the transcription factor sterol regulatory element binding protein (SREBP) and regulation of the triglyceride and cholesterol pathways.
Treating hepatic cells again for 24 hours with anti-ApoA-1 IgG antibodies or control IgG antibodies, or leaving them untreated, showed that anti-ApoA-1 antibodies were associated with “dramatic”” increases in the active form of SREBP.
They also found that expression of two key enzymes in the triglyceride pathway, fatty acid synthetase and glycerol phosphate acyltransferase, was substantially decreased in the presence anti-ApoA-1 antibodies.
In both experiments, the untreated hepatic cells and those exposed to control IgG antibodies showed no significant changes.
“These results suggest that negative feedback…turns off these enzymes, probably due to the lipid overload that is found in the cells after 24 hours of anti-ApoA-1 treatment,” Pagano said.
Finally, the researchers observed that anti-ApoA-1, but not control antibodies, were associated with increases in inflammatory markers in liver cells.
Specifically, exposure to the antibodies was linked to an approximately 10-fold increase in interleukin (IL)-6 levels, as well as an approximate 25-fold increase in IL-8, and around a sevenfold increase in tumor necrosis factor-alpha.
Pagano suggested that the inflammatory effects are “probably mediated by binding anti-ApoA-1 antibodies to toll-like receptor 2, which has been previously described in macrophages.”
No funding was declared. The study authors have disclosed no relevant financial relationships.
European Atherosclerosis Society 2021 Virtual Congress: Abstract 704. Presented May 31, 2021.
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Adverse events are thoroughly reviewed and Pfizer meets regularly with the Vaccine Safety Department of the Israeli Ministry of Health to review data, it said.
Israel had held off making its 12 to 15-year-old population eligible for the vaccines, pending the Health Ministry report.
In parallel to publishing those findings, a ministry committee approved vaccinating the adolescents, a senior official said.
“The committee gave the green light for vaccinating 12- to 15-year-olds, and this will be possible as of next week,” Nachman Ash, Israel’s pandemic-response coordinator, told Radio 103 FM. “The efficacy of the vaccine outweighs the risk.”
(KXAN) — A new study out of Spain has uncovered what it calls a potential link between pregnant women using the drug acetaminophen — which many people know by the brand name Tylenol — and then their child developing autism or attention-deficit/hyperactivity disorder (ADHD).
Acetaminophen is also commonly known by the name paracetamol. It’s one of the most commonly used pain relievers in the world.
Researchers from the University of Barcelona studied health data from more than 73,000 mother-child pairs across Europe. They found that unborn children exposed to acetaminophen were 19% more likely to be on the autism spectrum and 21% more likely to show signs of ADHD.
“The most consistent pattern of results was observed for the association between prenatal acetaminophen exposure and ADHD symptoms,” the researchers wrote. They said the link was there in both boys and girls but was slightly stronger in boys.
The researchers did warn that this study is just a possible link. Readers should not take their findings as definitive proof.
“Our findings need to be interpreted with caution given the limitations of our study,” the researchers wrote.
Author: Wes Wilson
This post originally appeared on KXAN Austin
The astronomical rally in Ether (ETH) is not showing any signs of slowing down. The bulls easily cleared the overhead hurdle at $ 4,000 today, which also pushed the biggest altcoin’s market dominance to over 19%.
It is not only Ether that is witnessing sharp buying from traders. Litecoin (LTC) and Cardano (ADA) have also risen new all-time highs, suggesting a broad-based altcoin rally.
However, Bitcoin (BTC) seems to have lost its momentum as it continues to struggle near the $ 60,000 mark. That has pulled its market dominance to below 44% for the first time since July 2018.
However, the recent underperformance of Bitcoin has not shaken the long-term bulls. Morgan Creek Capital Management founder and CEO Mark Yusko recently said in an interview with CNBC that Bitcoin will rival the “monetary value” of gold.
“If gold’s monetary value is $ 4 trillion, then digital gold should move up to that total,” Yusko added. That means Bitcoin will have to rise to $ 235,000 in the future to fulfill Yusko’s prediction.
Let’s analyze the charts of the top-10 cryptocurrencies to spot the critical support and resistance levels.
Bitcoin has been sandwiched between the moving averages and the $ 58,966.53 resistance for the past two days. This tight range trading suggests a status of equilibrium between the bulls and the bears.
If the uncertainty resolves to the downside, the BTC/USDT pair could drop to $ 52,323.21. The bulls will try to defend this support and if they succeed, the pair could extend its consolidation between $ 52,323.21 and $ 58,966.53 for a few more days.
The gradually rising 20-day exponential moving average ($ 56,611) and the relative strength index (RSI) near the midpoint suggest a balance between supply and demand.
This balance may shift in favor of the bulls if the price sustains above $ 58,966.53. That could result in a march to the all-time high at 64,849.27. A break above this resistance may signal the resumption of the up-move.
Conversely, a break below $ 52,323.21 may indicate the start of a deeper correction to $ 46,985. A break below this support could trigger panic selling.
Ether’s rally has continued unabated. After forming a Doji candlestick pattern on May 9, the bulls have asserted their dominance today and pushed the price to a new all-time high. The sharp rally of the past few days has pushed the RSI above 83.
A deeply overbought level on the RSI indicates a buying frenzy as traders fear missing out on the rally. Generally, such rallies top out after the last bull has purchased. The ETH/USDT pair could rise to $ 4,528.97 and then to the psychological level at $ 5,000.
The first sign of the bullish momentum fading could be a correction that lasts for more than three days. A break below the 20-day EMA ($ 3,173) will signal the start of a deeper correction.
Binance Coin (BNB) rose to a new all-time high at $ 691.77 today but the bulls are struggling to sustain the price above the breakout level at $ 680. The long wick on the day’s candlestick suggests a lack of demand at higher levels.
The upsloping moving averages indicate that buyers are in control, but the negative divergence on the RSI suggests the bullish momentum may be weakening. A break and close below the 20-day EMA ($ 599) could be the first sign of a deeper correction.
On the other hand, if the price rises from the current level or the 20-day EMA, the bulls will make one more attempt to push and sustain the BNB/USDT pair above $ 680. If they succeed, the pair could embark on a journey toward $ 760 and then $ 808.57.
Dogecoin (DOGE) witnessed a sharp dump on May 9 but the bulls aggressively defended the 20-day EMA ($ 0.44) as seen from the long tail on the day’s candlestick. However, the buyers could not extend the recovery today and the price has resumed its journey toward the 20-day EMA.
The 20-day EMA is gradually flattening out and the RSI has declined below 58, indicating the bullish momentum is weakening.
If the DOGE/USDT pair again rebounds off the 20-day EMA, it will suggest strong buying at lower levels. Such a move could keep the pair range-bound for a few more days.
This view will invalidate if the bears sink the price below the 20-day EMA. if that happens, the pair could drop to the 61.8% Fibonacci retracement level at $ 0.38.
XRP has repeatedly broken above the downtrend line since May 6 but the bulls have not been able to sustain the breakout. This suggests that traders may be using the rallies to lighten their long positions.
The buyers will have to push and sustain the price above $ 1.66 to enhance the prospects of a retest of the 52-week high at $ 1.96. The gradually upsloping 20-day EMA ($ 1.45) and the RSI above 56 indicate a minor advantage to the bulls.
This positive view will nullify if the price turns down and breaks below the 20-day EMA. Such a move will suggest that supply exceeds demand. The XRP/USDT pair could then drop to the 50-day simple moving average ($ 1.16).
Cardano made a large outside day candlestick pattern on May 9, indicating strong buying at the breakout level of $ 1.48. However, the bulls have not been able to sustain the momentum today and the altcoin has formed an inside-day candlestick pattern.
If the bulls do not give up much ground from the current level, it will signal strength and that could enhance the prospects of the resumption of the uptrend.
The rising 20-day EMA ($ 1.45) and the RSI in the overbought territory also indicate the path of least resistance is to the upside. A break above $ 1.83 may open the doors for a rally to $ 2 and then $ 2.25.
Contrary to this assumption, if the ADA/USDT pair turns down and breaks below the 20-day EMA ($ 1.45), it will indicate a bull trap. That could pull the price down to $ 1.28 and then to $ 1.
Polkadot (DOT) is stuck between the moving averages and the $ 42.28 overhead resistance. This tight range trading near the stiff resistance is a positive sign as it shows that traders are in no hurry to dump their long positions.
If the bulls can thrust and sustain the price above $ 42.28, it will suggest that demand exceeds supply. That could result in a rally to the all-time high at $ 48.36 where the bears are again likely to mount a stiff resistance.
However, if the buyers push the price above $ 48.36, the DOT/USDT pair could start its journey to $ 58.06.
Alternatively, if the price breaks below the moving averages, the pair could drop to $ 34.36 and then to $ 32.56. If that happens, the pair may extend its stay inside the $ 26.50 to $ 42.28 range for a few more days.
Bitcoin Cash (BCH) is facing stiff resistance near the 52-week high at $ 1,600.89 as seen from the long wick on today’s candlestick. If the price slips below $ 1,400, the altcoin could drop to the 38.2% Fibonacci retracement level at $ 1,263.10 and remain range-bound for a few days.
The first sign of weakness will be a break below $ 1,263.10 and the advantage will shift in favor of the bears if the BCH/USDT pair slips below the 20-day EMA ($ 1,134).
However, the upsloping moving averages and the RSI in the overbought zone suggest the path of least resistance is to the upside.
If the price rises from the current level or from $ 1,400 and breaks above $ 1,600.89, the pair could start the next leg of the uptrend, which has a target objective at $ 2,147.36.
Litecoin surged above the resistance line of the ascending broadening wedge pattern on May 9, indicating a pick-up in momentum. The altcoin hit a new all-time high at $ 412.76 today but the long wick on the candlestick suggests profit-booking at higher levels.
If the LTC/USDT pair rebounds off the breakout level, it will suggest that the bulls are buying every minor dip. That will increase the possibility of the resumption of the uptrend with the next target at $ 463.31 and then $ 500.
On the contrary, if the price re-enters the wedge, it will suggest that the breakout on May 9 was a bull trap. That could pull the price down to the 20-day EMA ($ 309). A strong rebound off this level will suggest the sentiment remains positive while a break below the 20-day EMA will clear the path for a drop to the support line of the wedge.
The bulls pushed Chainlink (LINK) above the resistance line of the ascending channel on May 5 but could not build up on the breakout. After hesitating for a few days, the bulls made a decisive up-move on May 9 and pushed the altcoin to $ 52.42.
However, the bulls again failed to sustain the rally and the bears are trying to pull the price back into the ascending channel. If they succeed, the LINK/USDT pair may drop to the 20-day EMA ($ 43).
If the price rebounds off the 20-day EMA, the bulls may make one more attempt to resume the uptrend. On the contrary, a break below the 20-day EMA will suggest the current breakout was a bull trap. The pair could then drop to the support line of the channel.
The views and opinions expressed here are solely those of the author and do not necessarily reflect the views of Cointelegraph. Every investment and trading move involves risk. You should conduct your own research when making a decision.
Over the past few weeks, many players seem to have just found out that Link can actually ride large barrels in the game. It appears to have surprised everyone. Some commenters in the below Reddit post didn’t even know there were barrels this big in Breath of the Wild.
This is where you can find one of these giant barrels, according to the individual who posted the Reddit video (we also found it ourselves outside the Woodcutter’s house):
“I found this one on the Great Plateau near “Old Man’s hut”, IICRC there was one located at some ruins…
“There were also other comments that mentioned you can find it near somewhere on Lanayru Wetlands and Eventide Island.”
And here’s another look at it in action, courtesy of a few others – including Nintendo Life video producer, Jon Cartwright:
Over the past week, several traders bought Dogecoin (DOGE) leading up to Elon Musk’s Saturday Night Live appearance as they expected a pump. However, the mention of Dogecoin during the monologue by Musk did not produce the rally traders were looking for and professional traders may have dumped their positions on novice traders who were expecting a breakout.
Dogecoin dumped to an intraday low at $ 0.41 today, losing over 34% from the previous day’s close. Since then, the meme coin has been trying to stage a recovery and has risen to $ 0.54. The sharp fall in Dogecoin price shows that buying the hype, without any major fundamental reason, could result in stomach-churning volatility.
On the other hand, Ether (ETH) extended its up-move further, faltering just below $ 4,000, while Bitcoin (BTC) again fell short of the $ 60,000 mark, indicating strong selling on every minor rally. A few days of range-bound action in Bitcoin is a positive sign as it may set the stage for the next leg of the uptrend.
With Ether leading the altcoin charge, let’s look at the top-5 cryptocurrencies that may outperform in the short term.
Bitcoin broke above the downtrend line on May 8 but the bulls are finding it difficult to clear the hurdle at $ 58,966.53. The immediate support on the downside is at the moving averages. If the price rebounds off the 20-day exponential moving average ($ 56,387), the bulls will make one more attempt to push the price above $ 58,966.53.
If they succeed, the BTC/USDT pair could start its journey toward the resistance line of the ascending channel at $ 67,000. The price has turned down from the resistance line on two previous occasions, hence the bears will again try to defend this level. The momentum will pick up after the buyers push the price above the channel.
However, the flattish moving averages and the relative strength index close to the midpoint show a lack of bullish momentum. If the bears pull the price below the 20-day EMA, the pair could drop to $ 52,323.21.
A strong rebound off this level will suggest buying at lower levels and that could result in a range-bound action between $ 52,323.21 and $ 58,966.53 for a few days.
On the other contrary, a break below $ 52,323.21 may open the doors for a fall to the support line of the ascending channel and then to $ 46,985 where buyers may step in to arrest the decline.
The 4-hour chart shows the bears are defending the $ 58,966.53 overhead resistance. If they can sink the price below the 50-simple moving average, the pair could drop to $ 55,000 and then to $ 52,323.21.
The flattish moving averages and the RSI near the midpoint suggest a balance between supply and demand. However, if the price rebounds off the current level and rises above $ 58,966.53, the pair could pick up momentum and rally toward the target objective at $ 65,012.18.
Binance Coin (BNB) is in a strong uptrend and the moving averages indicate the path of least resistance is to the upside. Although the negative divergence on the RSI is flashing a warning sign, the setup will not come into play until the price retreats and shows weakness.
If the bulls thrust the price above $ 680, the BNB/USDT pair may start the next leg of the uptrend that could reach $ 808.57. This positive view will invalidate if the pair turns down and breaks below the 20-day EMA ($ 592).
If that happens, the short-term traders may dump their positions, resulting in a decline to the 50-day SMA ($ 466). This is an important support to watch out for because the price has not closed below the 50-day SMA since Dec. 13, 2020. A break below $ 428 may signal that a top is in place.
The 4-hour chart shows the pair is stuck between $ 600 and $ 680. The 20-EMA has started to turn up and the RSI is in the positive territory, indicating the bulls have the upper hand. If the bulls can push and close the price above $ 680, the pair may rally to $ 760.
Alternatively, if the price turns down from the current level and slips below the moving averages, the pair may correct to $ 600. A bounce off this level could extend the consolidation for a few more days.
Cardano (ADA) had been stuck between the $ 1 to $ 1.48 range for the past many weeks, before breaking out on May 6. This suggests the equilibrium between the bulls and the bears resolved in favor of the buyers.
That does not mean the bears have given up yet. They attempted to pull the price back below $ 1.48 on May 7 and today. However, the long tail on the day’s candlestick suggests the bulls have successfully flipped $ 1.48 into support.
If the buyers sustain the price above $ 1.74, the ADA/USDT pair could rally to $ 2 and then $ 2.25. This bullish view will nullify if the price turns down and slips below the 20-day EMA ($ 1.42). Such a move could trap the aggressive bulls, resulting in a drop to $ 1. A rebound off this level could keep the pair range-bound for a few more days.
The moving averages on the 4-hour chart are sloping up and the RSI is in the positive territory, indicating the bulls are in control. If the buyers sustain the price above $ 1.75, the momentum may pick up.
Conversely, if the price turns down from the current level, the pair may drop to the 20-EMA and then to the $ 1.48 support. A bounce off this support could result in a tight range trading between $ 1.48 and $ 1.75. The short-term bullish sentiment may nullify if the bears sink the price below the 50-SMA.
Litecoin (LTC) has been trading inside an ascending broadening wedge pattern. Although the bears have been defending the resistance line of the wedge for the past few days, the positive sign is that the bulls have not given up much ground.
If the bulls can drive and sustain the price above $ 372.53, the LTC/USDT pair could start the next leg of the uptrend which could reach $ 400 and then $ 463.31. The rising moving averages and the RSI in the overbought territory suggest the path of least resistance is to the upside.
Contrary to this assumption, if the bulls fail to sustain the price above the resistance line, the short-term traders may dump their positions. That may result in a drop to the 20-day EMA ($ 298). A break below this support could open the gates for a decline to the 50-day SMA ($ 247).
The 4-hour chart shows the pair is consolidating between $ 330.50 and $ 372.50. The bears have successfully defended the overhead resistance and are pulling the price toward the 20-EMA. If the price rebounds off this support, the bulls will make another attempt to resume the uptrend.
Conversely, a break below the 20-EMA could pull the price down to $ 330.50. A rebound off this support may extend the stay of the pair inside the range for a few more days. On the other hand, a break and close below $ 330.50 could signal the start of a deeper correction. The first support is at the 50-SMA and then $ 290.
Chainlink (LINK) is in an uptrend and it had hit a new all-time high at $ 51.96 on May 7. During a strong uptrend, corrections are shallow and the price tends to consolidate in a tight range before resuming the up-move.
The long wick on the May 7 candlestick showed selling at higher levels and that was followed by an inside-day candlestick pattern on May 8, indicating indecision among the bulls and the bears. However, the upsloping 20-day EMA ($ 42) and the RSI in the overbought zone suggest that bulls have the upper hand.
If the bulls can sustain the price above $ 51.96, the LINK/USDT pair could resume its uptrend. The next target objective on the upside is $ 66.74.
On the contrary, if the price turns down from the current level and breaks the $ 46 support, the pair may drop to the 20-day EMA. A strong bounce off this support will suggest the sentiment remains positive. However, a break below the 20-day EMA will indicate the short-term momentum has weakened and a drop to the 50-day SMA ($ 35) is likely.
The 4-hour chart shows the price has broken out of the $ 46 to $ 50 range. This suggests the start of the next leg of the uptrend, which has an immediate target at $ 54. The 20-EMA has started to turn up and the RSI is above 67, indicating the bulls are in control.
However, if the price turns down and slips below $ 50, it will indicate the markets have rejected the higher levels. That may result in further selling that could pull the price down to the 50-SMA. A break below this level will suggest advantage to the bears.
The views and opinions expressed here are solely those of the author and do not necessarily reflect the views of Cointelegraph. Every investment and trading move involves risk, you should conduct your own research when making a decision.