Tag Archives: Trials

Pfizer Covid vaccine: 'Few people in clinical trials went to hospital or died', says CDC

The Centres for Disease Control and Prevention (CDC) pointed out that “few people in the clinical trials went to the hospital or died” following a jab of the Pfizer vaccine. However, “data suggest that people who got the Pfizer vaccine were less likely to have these more serious outcomes compared to people who got the saline placebo”. Severe side effects – ones that affected a person’s ability to do daily activities – were reported in some people.
Side effects should subside within a few days after they appear, but the vaccine has been proven to be around 95 percent effective against Covid.

As more data becomes available about how well the Pfizer vaccine works in real-world conditions, the CDC will continue to provide updates.

To deal with non life-threatening side effects, over-the-counter painkillers should suffice.

In order to reduce discomfort in the injected arm, the CDC advises to “apply a clean, cool, wet washcloth over the area”.


It may seem counterintuitive, but the CDC also recommends using or exercising your sore arm.

If you suffer from a fever post injection, the CDC suggests to “drink plenty of fluids” and to “dress lightly”.

“Side effects after your second shot may be more intense than the ones you experienced after your first shot,” warned the CDC.

In particular, the second shot of the Pfizer vaccine is more likely to lead to fever, chills, tiredness and a headache.

There are instances where you are recommended to contact your GP or healthcare provider.

For instance, if the redness or tenderness of the injection site gets worse after 24 hours, it’s time to call the doctor’s clinic.

Furthermore, if the side effects don’t go away after a few days, you’re recommended to contact your healthcare service.

The CDC reminded people that “it takes times for your body to build protection after any vaccination”.

People are only considered fully vaccinated two weeks after their second shot of the Pfizer vaccine.

During this time, it’s imperative to keep to social distancing guidelines and adhering to hygiene safety.

This requires wearing a face mask in enclosed public spaces, trying to keep your distance from others, and washing your hands often.

Do bear in mind that the Pfizer vaccine is an mRNA jab, meaning nobody is given the live virus that causes Covid.

This post originally appeared on Daily Express :: Health Feed
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Destiny 2 Trials of Osiris rewards and loot report ahead of Season 14 release

The latest Destiny Trials event is launching soon and will include the next round of armour pieces and Adept weapon options.

May 7 will see Guardians return to battling in 3vs3 Crucibles with a chance of unlocking the best Flawless loot.

Gamers will have to wait a little longer to learn the complete list of Destiny 2 rewards that will be available between now and May 11.

Destiny 2 fans will need to check back into the game at around 6pm BST to find out the latest news, including what map has been selected by Bungie.

For the end of Season 13, Saint-14 will remain the full-time Trials of Osiris vendor, residing in the Tower Hangar with his pigeons and ship.

And visiting him will be worth it for those who can smash through the Crucible and score some wins as Saint’s inventory updates with Trials Passages, Bounties, and the option to turn in Trials Tokens.

Last week saw Bungie offer The Exile’s Curse Fusion Rifle as a three-win weapon, and the Adept version of the same weapon as the Flawless reward.

Meanwhile, we won’t know the map selection until Trials of Osiris is back, and it will take a while for Guardians to work out the loot list.

That’s because Bungie doesn’t share what rewards are included in the Trials across any platforms.

Instead, it’s up to gamers to share the full list of loot that will be available from today, until the Weekly Reset on May 11.

This will also be the date that Bungie launches Destiny 2 Season 14 – Season of the Splicer.

The development team released a new rewards preview this week for the upcoming season, which will be dominated by Vex-smashing action.

“Loot is the name of the game for many a Guardian, so let’s get down to business. We’ll be working with the Fallen this Season, and we’ve got new armour pieces to earn. If you’ve ever wanted to embrace the Splicer lifestyle, this Season will be your chance.

“Previously, you would earn this armour by levelling your Season Rank and unlocking new pieces on the Seasonal Track. Moving forward, Seasonal Armor will be earned from Seasonal activities.

“You’ll also be able to guarantee pieces from these sets using Focused Umbral Engrams. Season Rank levels that once featured armour have been updated with packages of Glimmer, Legendary Shards, Upgrade Modules, Exotic Engrams, Enhancement Cores, and Enhancement Prisms. Universal Armor Ornaments will continue to be earned towards the end of the Season Pass.

“Now, let’s talk tools of destruction. There’s still gold to find in them Seasonal Rank hills. On the Seasonal Track, there will be three weapons to earn. Season Pass owners will unlock the new Exotic Sidearm on day one of the Season as soon as they claim their first reward. Additionally, the new Shotgun and Heavy Machine Gun will be up for grabs as you level up.

“If you want a full loadout of this style, we’ve got you covered. New weapons will be available through Umbral Engrams and Override completions.”

Expect more news regarding the new Season of Destiny 2 in the coming weeks from Bungie for PS4, Xbox One and PC gamers.

This post originally appeared on Daily Express :: Entertainment Feed

Reports of menstrual cycle changes after COVID vaccine

Author: KTRK, This post originally appeared on ABC13 RSS Feed

Reports of menstrual cycle changes after COVID vaccine

SAN FRANCISCO — On Monday, our sister station KGO-TV reported that some women are noticing changes in their menstrual cycles after getting COVID-19 vaccines.

Since then, hundreds of people have commented on the report, and women continue to express concern about long and heavy periods and changes in cycle timing.

A hematologist in Southern California reached out to KGO with a possible explanation and advice.

PREVIOUS ARTICLE: OBGYN explains why a COVID vaccine might affect menstrual cycles

“Inflammatory reaction has been noticed with the COVID vaccine. We know that because many, including myself after the second vaccine, developed some mild flu like symptoms,” said Dr. Akshat Jain, a hematologist at Loma Linda University School of Medicine.

Dr. Jain specializes in bleeding disorders in adolescent women and explained that inflammatory cells triggered by the vaccine could affect hormones.

“That inflammation, has a potential or potentially can modulate estrogen response, which could be the link between certain women having heavy periods after the vaccine,” she explained.

Dr. Jain recommends that women experiencing heavy bleeding see their doctor for a complete blood count and estrogen test.

VIDEO: Women more likely to experience serious side effects from COVID-19 vaccine, CDC study reveals

“It’s an easily fixable problem,” Dr. Jain said. “So while, as scientists figure out the exact mechanism, which might take months, I think these are two actionable items that just need to be to be said out loud.”

“There’s a long history of us not doing a great job at studying women in research studies because of some of this complexity,” said University of California San Francisco OBGYN, Dr. Heather Huddleston, who specializes in reproductive endocrinology.

Dr. Huddleston wishes the vaccine makers had collected data about menstrual cycles during the randomized trials.

“The train sort of left the station on that because we are now recommending the vaccine for everybody. So it will be very hard for us to generate a control group to answer this question,” she said.

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Dr. Huddleston says she’s been thinking about ways to collect new data via apps that many women use to track menstrual cycles, saying, “We could look at just sort of what is the baseline rate of people having irregular cycles, or cycles that are different, and look at whether we’re noticing changes in the population of women who’ve gotten the vaccine in the last few months.”

When asked whether she thinks the vaccine is harmful to women who are experiencing these cycle changes and if it affect fertility, Dr. Huddleston said, “No. So what I would say is that just in the same way that some women and men have had a sore arm, after the vaccine, or maybe felt tired, maybe had even a low grade fever, these are all things that people experienced in a very short term way after the vaccine. And within a few days, people are back to normal.”

“That is a transient reaction to the vaccine,” she said. “And it’s a representation of your immune system being activated. If, and it’s still a big if. But if these menstrual cycle changes are also sort of linked into that upregulation of the immune system that we’re seeing, then I would view that in the same way I would view a sore arm. It’s a nuisance, it’s troubling in that moment, but it’s not a representation of something that’s going to continue. It’s not a representation of any sort of permanent harm or damage. There is no reason to think there’s reason to be concerned over time, and there’s no reason to think that there’s any impact on fertility.”

Dr. Huddleston says women should continue to get vaccinated.

Copyright © 2021 KTRK-TV. All Rights Reserved.

‘A necessary step’: Japan starts trials on issuance of national digital currency

The Bank of Japan (BOJ) said on Monday that it has begun experiments to study the feasibility of issuing its own digital currency. The move sees it join other global central banks in exploring options in the digital sector.

According to the regulator, the first phase of experiments will be carried out until March 2022 and will focus on testing the technical feasibility of issuing, distributing, and redeeming a central bank digital currency (CBDC). It will then move to the second phase of experiments, which will scrutinize more detailed functions, such as whether to set limits on the amount of CBDC each entity can hold.

The BOJ’s plan to begin experimenting on how to operate its own digital currency was announced in October. Its Executive Director Shinichi Uchida said last month that if necessary, the bank will launch a pilot program that involves payment service providers and end users.

“While there is no change in the BOJ’s stance [that] it currently has no plan to issue CBDC, we believe initiating experiments at this stage is a necessary step,” Uchida told a committee of policymakers and bank lobbies looking into CBDC.
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The Bank of Japan’s announcement comes as global central banks are forging ahead with initiatives for developing their own digital currencies. They seek to modernize financial systems and ward off the threat from cryptocurrencies, as well as speed up domestic and international payments.

READ MORE: ‘Highest form of money’: Russia set to have first digital ruble prototype this year

The Central Bank of Russia (CBR) plans to launch its first digital ruble prototype this year. The CBR is set to publish the roadmap for development of the digital currency soon, and its prototype should be ready by autumn, according to the head of the State Duma Committee on the Financial Market, Anatoly Aksakov.

In China, massive pilot testing of digital yuan is currently underway in major cities across the country. The nation’s central bank plans to have its sovereign digital currency ready in time for the 2022 Winter Olympics.

For more stories on economy & finance visit RT’s business section


Destiny 2 Trials of Osiris rewards news this week come with a future update

This week’s Destiny 2 Trials of Osiris will be kicking off very soon, complete with the latest armour pieces and weapons.

The event has undergone some changes since its return and has had more success in drawing gamers back each week.

And while we don’t know what combo of Trials of Osiris rewards will be made available today, we know when it will be best to check it all out.

Bungie confirmed earlier in Season of the Chosen, Saint-14 is the full-time Trials of Osiris vendor, residing in the Tower Hangar with his pigeons and ship.

And visiting him will be worth it for those who can smash through the Crucible and score some wins as Saint’s inventory updates with Trials Passages, Bounties, and the option to turn in Trials Tokens.

Some things have also stayed the same, with Bungie making sure that the Trials of Osiris playlist becomes active each week from Friday to Tuesday.

The map rotations continue each week, although Bungie has made changes to the weapons you can pick up during an event.

Last week saw both The Messenger and The Adept Messenger weapons made available.

The normal Messenger could be unlocked by putting together three wins, the fancier Adept version needed a flawless run of seven wins.

We don’t know what new rewards will be added to the roster this week, but we do know that gamers will want to check back at 5pm BST for the latest news.

Bungie never shares a full list of rewards but it won’t take Guardians long to blitz through the Crucible and share the news.

The development team behind the hit shooter has also confirmed how they plan to make changes to Trials Of Osiris during Season 14.

This includes tweaks being made to perks like Celerity, with Bungie confirming this list:

Nightfall weapons:

  • Bottomless Grief grants a permanently active +30 to Magazine.
  • Bottomless Grief is now a fixed alternate perk in the left column on Adept drops of Nightfall weapons (i.e. you can switch between that and the randomly rolled perk in the inspection screen).

Trials weapons:

  • Celerity grants a permanently active +20 to both Reload and Handling.
  • Celerity is now a fixed alternate perk in the right column on Adept drops of Trials weapons (i.e. you can switch between that and the randomly rolled perk in the inspection screen).
  • Moving forward, we’re not done with origin perks, and hope to have something that better achieved our goals in a future release.
Speaking more about the upcoming changes and what can’t be done, Bungie added that there were limitation in what can be done to make them more intrinsic to Trials and Nightfall weapons, adding:

“For performance reasons, we have a maximum number of perks that can run on a character at a time. Legendary weapons have a threshold per weapon, and many of them are right at the limit – adding a perk on top of that without taking one away causes Bad Things to Happen, in the form of random parts of perks turning off.

“Adding a new perk column to weapons from a specific source introduces power creep, and pretty soon we’d end up having to do the same to weapons from other sources.

“Adding a new perk column to ONLY Adept weapons would work against the third goal of Adept weapons, and we believe would feel bad for players dying to Adept weapons that are able to stack Celerity with things like Outlaw and Rampage.”

Vaccine side effects: High fever, chills and dizziness reported in new Novavax trials

A deal announced on Monday with the pharmaceutical company GlaxoSmithKline (GSK) will manufacture up to 60 million doses of the Novavax vaccine. The vaccine is already being produced at a Fujifilm facility in Stockton-on-Tees, though the UK regulator has yet to approve the jab. What are the side effects of the Novavax vaccine?

President and Chief Executive Officer for Novavax said: “With today’s results from our UK Phase three and South Africa Phase 2b clinical trials, we have now reported data on our COVID-19 vaccine from Phase 1, 2 and 3 trials involving over 20,000 participants.

“In addition, our PREVENT-19 US and Mexico clinical trial has randomised over 16,000 participants toward our enrolment goal of 30,000. NVX-CoV2373 is the first vaccine to demonstrate not only high clinical efficacy against COVID-19 but also significant clinical efficacy against both the rapidly emerging UK and South Africa variants.”

He continued: “NVX-CoV2373 has the potential to play an important role in solving this global public health crisis.

“We look forward to continuing to work with our partners, collaborators, investigators and regulators around the world to make the vaccine available as quickly as possible.”

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Initial side effects from the Novovax vaccine include:

  • High fever
  • Chills
  • Dizziness

The Novavax coronavirus vaccine is nearly 90 percent effective at preventing COVID-19.

Though the vaccine worked against all variants, it was less effective at preventing infections caused by the B.1.351 variant dominating in South Africa. Still, the vaccine, which produces a robust immune response, was effective at preventing severe cases of COVID-19.

Novavax is already working on a new vaccine that will target the new variant and expects to start testing it in a few months.

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Covid vaccine update: Trials for Pfizer vaccine begin for children under the age of 12

Researchers will then evaluate the safety and effectiveness of the selected dose levels in the next phase of the trial, with participants being randomly selected to receive the vaccine or a placebo.

After a six-month follow-up, children who received a placebo will then have the opportunity to receive the vaccine, the company said.

Pfizer’s vaccine has already been authorised for use in people aged 16 and older, and the company hopes to expand the vaccination age range by early 2022.

Moderna have also begun vaccine trials in children under the age of 12, making the announcement on 16 March.