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1 year later and 150 miles from Tokyo, Olympics set to get underway

A softball tripleheader, which includes Team USA facing Italy, will kick off the Olympic competition in Japan.

FUKUSHIMA, Japan — Skippy the yellow kangaroo with green paws was affixed to the first base dugout railing, watching the Australia Spirit become the first team to work out at Fukushima Azuma Baseball Stadium, seven weeks after they became first foreign athletes to arrive at the Olympics.

Coach Laing Harrow hit grounders and flies to his women starting at 9 a.m. Tuesday, exactly 24 hours before the eighth-ranked Aussies step to the plate when host Japan, the No. 2-ranked softball team, throws the very first pitch of the very first event of the pandemic-delayed Olympics.

The Games of the 32nd Olympiad were to have started last July 22 but were pushed back by the coronavirus pandemic. Despite many in Japan questioning whether it is wise with the virus still raging in the country, the International Olympic Committee is pushing ahead.

This ballpark, located about 150 miles north of Tokyo and similar to a big league spring training camp, has only several handfuls of the 11,000 athletes who are converging on the Tokyo Games. The stadium, 42 miles northwest of the location of the 2011 Fukushima Daiichi nuclear disaster, will host the first two days of the softball tournament and the opening day of the baseball event on July 28, with the remainder at the home of the Central League’s Yokohama DeNA BayStars, a big ballpark 17 miles from the capital.

In their bright yellow jerseys, the Aussies were excited to be about to get underway.

“It was disappointing for the girls, obviously, being postponed for a year,” Harrow said. “Some of them would have had plans from after August 2020. And, sure, it wasn’t in their plans to continue to be in the gym every day and training every day. But overall, the girls have really handled that well. And I think one thing we’re very good at is being adaptable.”

The top-ranked United States, seeking to regain the gold medal it lost when it was upset by Japan 3-1 in the 2008 final in Beijing, opens against No. 9 Italy in the second game of a tripleheader that ends with No. 5 Mexico against third-ranked Canada.

Host Japan took batting practice next on a broiling day with 95-degree heat and high humidity, followed by Italy, the United States, Mexico and Canada.

A 15-woman U.S. roster includes a pair of veterans: 38-year-old left-hander Cat Osterman, the last holdover from the 2004 gold medal-winning team, and 35-year-old left-hander Monica Abbott, who joined Osteman on the 2008 team.

Outfielder Janie Reed is the wife of Los Angeles Dodgers right-hander Jake Reed, who made his big league debut July 6, had six appearances and was optioned Monday to Triple-A Oklahoma City.

“The aspect of having 16 months, 17 months now since the decision to delay the Olympics has probably caused some environmental things to happen,” U.S. coach Ken Eriksen said. “Number one, the natural order of aging another year for some of the players as far as either enhanced, or maybe it has brought in some consternation, especially emotionally.”

The American team trained in the U.S. through June 20 and started in Japan on July 5 in Iwakuni, 525 miles southwest of Tokyo.

Canada’s team dispersed last March, didn’t gather again until January and landed in Japan on July 6.

“We relied on what many people did, just Zoom calls and just virtual communication and trying to stay connected, but fortunately this time gave way to a lot more individual preparation and a lot of learning and a lot of people pursuing knowledge and just continuing to perfect their craft,” said Canada outfielder Victoria Hayward, who trains at Proswings in Longwood, Florida, to take advantage of better weather. “So we feel very fortunate that we had a little bit of extra time to sharpen our axes and to work together and then in 2021 we’ve been able to be together for a majority of the year unbroken.”

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This post originally posted here CBS8 – Sports

A large-scale rescue effort is underway after the heaviest rainfall in a century caused flash floods to devastate parts of Western Europe

Fast moving torrents of water inundated entire towns and villages in western and southern Germany, causing buildings to collapse and leaving residents stranded, police said Thursday. At least 55 people have died in the severe flooding but authorities said that number is expected to rise.
Germany is worst hit with 49 dead, while six people died in Belgium. Luxembourg and the Netherlands are also affected.
In Germany’s worst hit Rhineland-Palatinate state, 1,300 people are “assumed” missing in the district of Ahrweiler, the local government said.
“In some areas we have not seen this much rainfall in 100 years,” Andreas Friedrich, a German weather service spokesman, told CNN. He added that “in some areas we’ve seen more than double the amount of rainfall which has caused flooding and unfortunately some building structures to collapse.”
Along with Rhineland-Palatinate, the German regions of North Rhine-Westphalia and Saarland were worst affected, Friedrich added.
Extreme rainfall totals were observed Wednesday into Thursday morning across much of western Germany and the Benelux region, with North Rhine-Westphalia and Rhineland-Palatinate seeing the highest rainfall totals, according to CNN meteorologist Brandon Miller.
Widespread swaths of these states saw 24-hour rainfall totals between 100 and 150 millimeters (3.9-5.9 inches), which represent more than a month’s worth of rainfall in this region.
Cologne recorded 154 millimeters (6 inches) of rainfall in only 24 hours ending Thursday morning, which is nearly double its monthly average for July of 87 millimeters (3.45 inches).
Locally heavier downpours resulted in extreme flash flooding. In Reifferscheid, an incredible 207 millimeters (8.1 inches) of rain fell in only nine hours, according to the European Severe Weather Database.

At least 30 dead in one German state

In North Rhine-Westphalia, Germany’s most populous state, 30 people have been found dead, a spokesman for the state government told CNN. According to the spokesman, at least 50 people were also injured in the floods and the number of people missing is unclear.
In Rhineland-Palatinate, at least 19 people were found dead, but “that number is expected to rise,” a spokesman for police in Koblenz told CNN.
On Thursday morning in the district of Bad Neuenahr-Ahrweiler, more than 1,000 police and emergency workers were called in, the local government said.
German Chancellor Angela Merkel, who is on her swansong visit to Washington, DC, described the deadly floods as a “catastrophe.”
“Here in Washington, my thoughts are also always with the people in our homeland,” Merkel said at a news conference on Thursday ahead of her meeting with President Joe Biden.
“Peaceful places are going through a catastrophe in these hours, one can say a tragedy. Heavy rainfall and floods are very inadequate words to describe this — it is therefore really a catastrophe.”
Merkel said the focus is on the rescue and immediate response to those affected by the floods, but added that she was in close contact with her country’s finance minister, Olaf Scholz, to work on a strategy for longer-term financial aid to help with recovery.
“I mourn for those who have lost their lives in this catastrophe — we do not yet know these numbers but there will be many,” she added.
Merkel’s spokesman Steffen Seibert offered condolences to the families of the victims. “I am shocked by the disaster that so many people in the flood areas have to endure. My sympathies go out to the families of the dead and missing,” Seibert wrote on Twitter.
A woman tries to move in a flooded street following heavy rains in Liege, Belgium.
Merkel’s visit is likely her last to the US before stepping down as Chancellor in the fall after 16 years in power.
Armin Laschet, the premier of North Rhine-Westphalia and the Conservatives’ candidate to succeed Merkel, visited affected parts of the region on Thursday.
“We will be faced with such events over and over, and that means we need to speed up climate protection measures, on European, federal and global levels, because climate change isn’t confined to one state,” Laschet said.

Six deaths in Belgium

In neighboring Belgium, at least six people died in floods in the southern region of Wallonia, CNN affiliate RTBF reported Thursday, citing the magistrate on duty at the Verviers prosecutor’s office and the governor of the Liège province.
The Wallonia region borders North Rhine-Westphalia. The floods have also disrupted Belgium’s national railway network, Infrabel, stopping services in the French-speaking south of the country, the company said Thursday in a press release.
People ride on a trailer as the Dutch fire brigade evacuate people from their homes in South Limburg.
Italy has begun sending search crews and vehicles to Wallonia, the Italian Civil Protection agency said in a statement.
King Philippe of Belgium visited the town of Chaudfontaine, in the province of Liège, after it was hit by severe flooding.
“We are really touched by the severity of the catastrophe,” Philippe said in an on-camera statement. “Our thoughts go to the victims, their families, and all the people who had to be evacuated in emergency from disaster areas.”
Workers from France’s Civil Protection Agency arrived in the Belgium province of Liege to assist with recovery and rescue efforts.
“Rescuers from the instruction and intervention unit of the (French) Civil Protection carry out the first reconnaissance operations,” the French Civil Protection agency said in a post on Twitter, shortly after their arrival. “They will be joined this evening by firefighters, divers and lifeguards.”
The European Union also activated the civil emergency response mechanism to help areas of Belgium affected by floods, the EU Commission said Thursday in a statement.
“Belgium, Luxembourg, Netherlands, Germany you can count on the EU’s help to face these dramatic floods. My thoughts are with the victims of these tragic events and with all who will have to rebuild what they have lost. I want to thank all rescue teams for their invaluable help and relentless efforts,” EU Council president Charles Michel tweeted Thursday.
UK Prime Minister Boris Johnson tweeted an offer of support on Thursday.
“Shocking to see the devastating flooding across Germany, Luxembourg, the Netherlands and Belgium,” Johnson tweeted.
“My thoughts are with the families of the victims and all those affected. The UK is ready to provide any support needed in the rescue and recovery effort.”
Shipping was also suspended on the River Rhine, one of Germany’s longest and most important arteries of industrial transport, according to NTV news.
Weather service spokesman Friedrich said the downpours were caused by cooler and warmer rainfall mixing. “It came from France at the beginning of the week to Germany and has been sitting over Germany for the last 48 hours,” he said.
“For now we predict the worst of the torrential rainfall is over, though more heavy rain is due in southwestern Germany on the upper reaches of the Rhine, (Thursday) and Friday,” he added.

Dutch city calls for two neighborhoods to evacuate

The city of Maastricht in the Netherlands has called on residents of the Heugem and Randwyck districts to leave their homes “as soon as possible” due to rising water in the river Meuse.
“The water in the Meuse is rising rapidly. We expect it to cross the quays at Randwyck/Heugem around 3 a.m.,” a news release from the city council of Maastricht said. “This means water will end up in the streets and homes.”
According to the Dutch statistics office, the population of the two neighborhoods is more than 9,000.

With climate change comes warmer air holding more water vapor

The extreme rainfall was the result of a slow-moving area of low pressure, which allowed a conveyor belt of warm and moist air to fuel powerful thunderstorms and bring heavy, long-lasting rainfall, according to the German national weather service, DWD.
Intense rainfall rates are becoming more common in the warming climate, as warmer air can hold more water vapor that is available to fall as rain.
“These kind of high-energy, sudden summer torrents of rain are exactly what we expect in our rapidly heating climate,” according to Hannah Cloke, a professor of hydrology at the University of Reading.
“The fact that other parts of the northern hemisphere are currently suffering record-breaking heatwaves and fires should serve as a reminder of just how much more dangerous our weather could become in an ever-warmer world,” Cloke said.
This story has been updated.

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This post originally posted here CNN.com – RSS Channel – HP Hero

EIB & KfW welcome progress in Lusaka sanitation project to double network access underway after decade of preparations

EIB & KfW welcome progress in Lusaka sanitation project to double network access underway after decade of preparations

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Upgrading sanitation key to improve public health and COVID protection; First financing for EUR 262 million scheme disbursed by EIB (www.EIB.org) and KfW; Team Europe partners welcome scheme’s vision and ambition.

New investment to transform public health in the Zambian capital Lusaka by improving access by 525,000 families to sanitation, expanding wastewater treatment at two new plants in Chunga and Ngwerere, and construction of 520 km of sewerage pipes will be accelerated by disbursement of financing for the Lusaka Sanitation Program by the European Investment Bank and a grant by the German Development Bank, KfW, on behalf of the Federal Republic of Germany.

“Expanding access to sewerage based sanitation is crucial to protect public health against a variety of waterborne diseases and COVID-19, ensure that thousands of, also poor, families across Lusaka benefit from better services and enable waste water treatment to continue during the either droughts or floods that would be hitting Zambia. The close cooperation with Zambian and international partners, including long-term financing and technical expertise provided by the European Investment Bank and KfW over recent years, is now delivering and contributing to Zambia’s Vision 2030.” said Eng. Jonathan Kampata, Managing Director of the Lusaka Water and Sanitation Company.

“The European Investment Bank is pleased to support the ambitious and visionary Lusaka Sanitation Program that will transform sanitation, public health, economic and social development in the Zambian capital. The scale of the project being implemented by the Lusaka Water Supply and Sanitation Company has required intensive technical preparations to maximise the impact of the scheme. Today marks a key milestone in the project that enables the first financing to be provided by EIB and KfW for rehabilitation of two waste water treatment works in the city and complement other parts of the city-wide scheme already underway. Accelerating high-impact sanitation investment is crucial to strengthen public health resilience to COVID-19 and deliver sustainable urban development.” said Thomas Ostros, European Investment Bank Vice President.

“Safe sanitation and hygiene are key aspects of a healthy and dignified life. Universal access to sanitation and hygiene by 2030 is a target of the Sustainable Development Agenda. Unfortunately, progress to date has been slow. Access rates to safe sanitation are not increasing fast enough, this amid the Covid-19 pandemic – and not just in Zambia. I am happy to announce the first disbursements of EIB and KfW funds, marking another important and timely step in the realization of the Lusaka Sanitation Programme. Increasing the waste water treatment capacity in Lusaka with support of the German government will form the backbone for upscaling access to safe sanitation and hygiene, particularly for poor households. By reducing the ground and surface water contamination the increased waste water treatment capacity will contribute to improving the quality of scarce water resources”, Anne Wagner-Mitchell, Ambassador of Germany to Zambia and Special Representative to COMESA.

Progress unlocking financing from international partners Progress in technical planning and project preparation for the Lusaka Sanitation Programme has enabled the first EUR 2.7 million to be disbursed by the European Investment Bank and German Development Bank, KfW. This is the first financing from the two international partners for the scheme.

The EIB will provide EUR 102.5 million and KfW EUR 33 million (grant) for the overall project, alongside the World Bank, African Development Bank, European Union, Bill & Melinda Gates Foundation and Government of Zambia.

Long-term sanitation investment to improve public health and social inclusion Implementation of the Lusaka Sanitation Program is a key part of the Zambian government’s Vision 2030 and National Development that will improve public health and social inclusion of vulnerable communities and address challenges faced by women and children.

Once complete the Lusaka Sanitation Program will reduce prevalence of water borne disease and pollution in local rivers.

Combating COVID-19 through community involvement Since the Covid-19 pandemic the Lusaka Sanitation Program has strengthened hygiene measures across the city by practising social distancing and changing public perception of hand washing.

400 hand sanitiser stations have been installed in public spaces such as markets, health centres, water points, and places of worship and over 600 water tap attendants have become coronavirus prevention ambassadors.
Distributed by APO Group on behalf of European Investment Bank (EIB).
Background information The European Investment Bank (EIB) is the long-term lending institution of the European Union owned by its Member States. It makes long-term finance available for sound investment in order to contribute towards EU policy goals.

KfW is one of the world’s leading and most experienced promotional banks. Established as a public law institution in 1948, the German Federal Government has an 80% stake and the German federal states have a 20% stake in the bank. The objective is to combat poverty, secure peace, protect the environment and the climate as well as ensuring fair globalization. KfW is a competent and strategic adviser for current development policy issues.

Press contacts: Nshamba Muzungu [email protected] Mobile:  +260 0977 408 554

EIB: Richard Willis [email protected] Tel.: +352 43 79 82155 Mobile:  +352 621 55 57 58

Website: www.EIB.org/press Press Office: +352 4379 21000 [email protected]

Embassy of the Federal Republic of Germany to Zambia Lisa Nolte Press Officer [email protected] +260 971 798 420

KfW Tom Woyack Portfolio Manager [email protected] +260 977 11 48 98

Follow us on: Twitter: https://twitter.com/EIB Facebook: https://bit.ly/2UD2VVm Instagram: https://bit.ly/3AX9fIa YouTube: https://bit.ly/2T8QFvw RSS: https://bit.ly/3r1TGtS LinkedIn: https://bit.ly/2VtdJ8V

EIB backing water investment across Zambia The EIB is also supporting new investment to upgrade and expand water and wastewater services provided by the Mulonga Water Supply and Sanitation Company on the Copperbelt Province.

The European Investment Bank has supported water, energy, transport, agriculture and private sector investment across Zambia since 1978 and KfW has been active in Zambia since 1965.

KfW: Increasing access to water, sanitation and hygiene in rural and urban Zambia German Cooperation, through KfW, is supporting the Zambian Government in its pursuit to ensure universal access to water, sanitation and hygiene in particular in Luapula, Eastern and Southern Provinces.

KfW has supported Zambia since 1965 on behalf of the German Federal Government with more than EUR 900 million, mainly financing infrastructure projects improving access to water and sanitation, transport and basic infrastructure in provinces and recently also energy and agriculture.

Dusseldorf Airport attack: Knifeman on run after stabbing – manhunt underway

The stabbing took place in front of the departures terminal, German magazine Focus has reported. One injured person has been taken to hospital. The victim was not seriously injured and was treated as an outpatient at a nearby hospital.

A spokeswoman for the federal police said the wanted man is being searched for jointly by federal and state police.

She added security camera footage showed two men walking towards an airport car park at 12.16pm local time, at which point the attack took place.

Andre Hartwich, spokesman for the Düsseldorf police, said the attack took place at a parking ticket machine in one of the airport’s car parks.

He added there was likely a dispute over territorial claims among homeless people.

Mr Hartwich said: “The names of both people are known to us.”

The spokesman added neither flight safety nor passengers are at risk.

Dusseldorf is the third biggest airport in Germany behind those located in Frankfurt and Munich.

In 2019, the airport handled 25.5 million passengers.

It is the main hub for Eurowings and a primary city for several other airlines.

Dusseldorf Airport has three passenger terminals and two runways that can handle wide-body aircraft up to the Airbus A380.

This is a breaking story. More to follow…

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Author: Paul Withers
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Murder suspect dies at Travis County jail, investigation underway into death

TRAVIS COUNTY, Texas (KXAN) — A suspect accused of murder died this weekend in the Travis County jail.

The Travis County Sheriff’s Office reported that staff members found Anthony Ryan Lilley, 31, unresponsive in his cell Saturday morning at the Travis County Correctional Complex. Deputies said employees started CPR and called EMS, who also responded but ultimately could not revive Lilley.

Police arrested Lilley on June 15 following a shooting that killed Travis Ray Clements in southeast Austin.

The sheriff’s office stated an investigation into the in-custody death is underway by the Internal Affairs Unit, the Criminal Investigations Division, the Texas Rangers and the Travis County Medical Examiner’s Office. An autopsy happened Sunday, and the sheriff’s office said the final report is pending toxicology results.

What happened on Todd Lane, according to police

According to the Austin Police Department, a woman called 911 on June 11, saying she had been robbed and shot. When officers arrived at 4123 Todd Lane, police found the woman and her husband, Clements, shot. Clements was unresponsive and was pronounced dead at the scene at 10:29 p.m., police say.

APD says the couple knew Lilley, and drove to the southeast Austin location with their three children to meet with the suspect. During the meeting, shots were fired hitting both victims. Lilley reportedly left the scene.

The children were taken to a family member by crisis counselors. The woman was taken by medics to a local hospital with non-life threatening injuries, police say.

Author: Will DuPree
This post originally appeared on KXAN Austin

Darlington schools on lockdown after child stabbed in 'serious assault' – manhunt underway

Wyvern School and West Park Academy were placed under lockdown by police. This was after emergency services were called to the scene of a stabbing incident on Collingsway, in Darlington at around 12.45pm today. A schoolboy in his mid-teens was taken to hospital with stab wounds.

A police operation is now underway to track down a suspect who has been identified by police.

A spokesperson for Durham Constabulary said: “Police were alerted to reports of a serious assault on Collingsway, in Darlington at approximately 12.45pm this afternoon (June 21).

“Colleagues from the ambulance service reported a stabbing incident and officers attended the scene.

“The victim, a male in his mid-teens was taken to James Cook University Hospital in Middlesbrough, suffering from stab wounds.

“A suspect has been identified and a police operation is under way to make an arrest.

“It is believed the suspect and victim are known to each other.”

Local councillors have warned there is an “ongoing incident” near Wyvern School and at West Park Academy. Emergency services have been called out to both schools.

Parents have also reportedly been urged to collect their children from their school.

Councillors for Brinkburn and Faverdale have said: “There is currently a serious ongoing incident within our ward in the West Park area with Police and Air Ambulance in attendance.

“Due to this incident Wyvern School is on lockdown and children need to be collected from school.

“Please be aware of necessary Police activity and stay safe,

“We will put further updates on this page as we are made aware.”

A police helicopter was seen flying near West Park Academy.

One parent of a pupil at West Park Academy shared a message sent to all parents at the school.

It read: “We have been notified by the police that there is a serious ongoing incident in West Park.

“We are currently in lockdown and all children are safe.

“We will not allow any children to leave the school without an adult, not an older sibling.

“Please pick up as normal with an adult.

“Top gate is locked.”

The parent added: “My wife went to pick up my daughter an all afternoon a police helicopter had been circling at about 200 feet very slowly.”

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This post originally appeared on Daily Express :: UK Feed

Photobiomodulation: Evaluation in Various Specialties Underway

Advances in photobiomodulation have propelled the use of therapeutic applications in a variety of medical specialties, according to Juanita J. Anders, PhD.

Dr Juanita J. Anders

During the annual conference of the American Society for Laser Medicine and Surgery, Anders, professor of anatomy, physiology, and genetics at the Uniformed Services University of the Health Sciences, Bethesda, Md., defined photobiomodulation (PBM) as the mechanism by which nonionizing optical radiation in the visible and near-infrared spectral range is absorbed by endogenous chromophores to elicit photophysical and photochemical events at various biological scales. Photobiomodulation therapy (PBMT) involves the use of light sources including lasers, LEDs, and broadband light, that emit visible and/or near-infrared light to cause physiological changes in cells and tissues and result in therapeutic benefits.

In dermatology, LED light therapy devices are commonly used for PBMT in wavelengths that range from blue (415 nm) and red (633 nm) to near infrared (830 nm). “Often, when PBMT is referred to by dermatologists it’s called LED therapy or LED light therapy,” Anders noted. “Some people are under the impression that this is different from PBMT. But remember: It’s not the device that’s producing the photons that is clinically relevant, but it’s the photons themselves. In both cases, the same radiances and fluence ranges are being used and the mechanisms are the same, so it’s all PBMT.”

The therapy is used to treat a wide variety of medical and aesthetic disorders including acne vulgaris, psoriasis, burns, and wound healing. It has also been used in conjunction with surgical aesthetic and resurfacing procedures and has been reported to reduce erythema, edema, bruising, and days to healing. It’s been shown that PBMT stimulates fibroblast proliferation, collagen synthesis, and extracellular matrix resulting in lifting and tightening lax skin.

According to Anders, French dermatologists Linda Fouque, MD, and Michele Pelletier, MD, performed a series of in vivo and in vitro studies in which they tested the effects of yellow and red light for skin rejuvenation when used individually or in combination. “They found that fibroblasts and keratinocytes in vitro had great improvement in their morphology both with the yellow and red light, but the best improvement was seen with combination therapy,” Anders said. “This held true in their work looking at epidermal and dermal markers in the skin, where they found the best up-regulation in protein synthesis of such markers as collagens and fibronectin were produced when a combination wavelength light was used.”

Oral Mucositis and Pain

PBMT is also being used to treat oral mucositis (OM), a common adverse response to chemotherapy and/or radiation therapy, which causes pain, difficulty in swallowing and eating, and oral ulceration, and often interrupts the course of treatments. Authors of a recently published review on the risks and benefits of PBMT concluded that there is consistent evidence from a small number of high-quality studies that PBMT can help prevent the development of cancer therapy–induced OM, reduce pain intensity, as well as promote healing, and enhance patient quality of life.

“They also cautioned that, due to the limited long-term follow-up of patients, there is still concern for the potential long-term risks of PBMT in cancer cell mutation and amplification,” Anders said. “They advised that PBMT should be used carefully when the irradiation beam is in the direction of the tumor zone.”

Using PBMT for modulation of pain is another area of active research. Based on work from the laboratory of Anders and others, there are two methods to modulate pain. The first is to target tissue at irradiances below 100 mW/cm2.

“In my laboratory, based on in vivo preclinical animal models of neuropathic pain, we used a 980-nm wavelength laser at 43.25 mW/cm2 transcutaneously delivered to the level of the nerve for 20 seconds,” said Anders, who is a past president of the ASLMS. “Essentially, we found that the pain was modulated by reducing sensitivity to mechanical stimulation and also by causing an anti-inflammatory shift in microglial and macrophage phenotype in the dorsal root ganglion and spinal cord of affected segments.”

The second way to modulate pain, she continued, is to target tissue at irradiances above 250 mW/cm2. She and her colleagues have conducted in vitro and in vivo studies, which indicate that treatment with an irradiance/fluence rate at 270 mW/cm2 or higher at the nerve can rapidly block pain transmission.

“In vitro, we found that if we used an 810-nm wavelength light at 300 mW/cm2, we got a disruption of microtubules in the DRG neurons in culture, specifically the small neurons, the nociceptive fibers, but we did not affect the proprioceptive fibers unless we increased the length of the treatment,” she said. “We essentially found the same thing in vivo in a rodent model of neuropathic pain.”

In a pilot study, Anders and coauthors examined the efficacy of laser irradiation of the dorsal root ganglion of the second lumbar spinal nerve for patients with chronic back pain.

They found that PBMT effectively reduced back pain equal to the effects of lidocaine.

Based on these two irradiation approaches of targeting tissue, Anders recommends that a combination therapy be used to modulate neuropathic pain going forward. “This approach would involve the initial use of a high-irradiance treatment [at least 250 mW/cm2] at the nerve to block the pain transmission,” she said. “That treatment would be followed by a series of low-irradiance treatments [10-100 mW/cm2] along the course of the involved nerve to alter chronic pathology and inflammation.”

Potential Applications in Neurology

Anders also discussed research efforts under way involving transcranial PBMT: the delivery of near-infrared light through the tissues of the scalp and skull to targeted brain regions to treat neurologic injuries and disorders. “There have been some exciting results in preclinical animal work and in small clinical pilot work that show that there could be possible beneficial effects in Parkinson’s disease, Alzheimer’s disease, depression, and improvement in cognition and memory after a brain injury, such as a TBI,” she said.

“Initially, though, there were a lot of questions about whether you could really deliver light to the brain through the scalp. In my laboratory, we used slices of nonfixed brain and found that the sulci within the human brain act as light-wave guides. We used an 808-nm near-infrared wavelength of light, so that the light could penetrate more deeply.” Using nonfixed cadaver heads, where the light was applied at the scalp surface, Anders and colleagues were able to measure photons down to the depth of 4 cm. “It’s generally agreed now, though, that it’s to a maximum depth of 2.5-3 cm that enough photons are delivered that would cause a beneficial therapeutic effect,” she said.

Anders disclosed that she has received equipment from LiteCure, grant funding from the Department of Defense, and that she holds advisory board roles with LiteCure and Neurothera. She has also served in leadership roles for the Optical Society and holds intellectual property rights for the Henry M. Jackson Foundation for the Advancement of Military Medicine.

This article originally appeared on MDedge.com, part of the Medscape Professional Network.

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This post originally appeared on Medscape Medical News Headlines

Turkey vs Italy LIVE: Updates as Euro 2020 gets underway in Rome

7:30pm:

Pre-match omens: Turkey

Turkey will be looking to break an unwanted run against Italy, who have been something of a nemesis over the years.

Turkey have never beaten the Azzurri, but have only encountered Italy once in a major tournament.

They’ll also be looking to end another negative stat, with Turkey’s four previous opening games at European Championships all ending in defeat.

Will that run continue tonight, or can Senol Gunes’ side start a new era with an historic victory?

7:00pm: The teams are in!

Much will be expected of Lille’s veteran striker Burak Yilmaz up front for Turkey, who will operate in a lone striker role after injury ruled Cenk Tosun out of the tournament.

Italy, meanwhile, have selected a pair of attacking full-backs to give extra impetus to the side moving forward, while Manuel Locatelli deputises for the injured Marco Verratti in midfield.

TURKEY (4-1-4-1): Cakir; Zeki Celik, Demiral, Soyuncu, Meras; Yokuslu; Karaman, Tufan, Yazizi, Calhanoglu; Yilmaz

ITALY (4-3-3): Donnarumma; Florenzi, Bonucci, Chiellini, Spinazzola; Barella, Jorginho, Locatelli; Berardi, Immobile, Insigne

6:20pm: Turkey’s head coach Senol Gunes says he hopes his side can “cause confusion” from the very start of the tournament by upsetting the Group A favourites.

“The result we get in the first match is important; a draw or a win can cause confusion in the group,” he told UEFA.com

“I hope so. I want to see our strength in the first match; even if we lose, it’s important to play well.

“I hope it’s going to be a great game, an enjoyable game, and that we win!”

His opposite number, former Manchester City boss Roberto Mancini, was typically cagey ahead of the opening match of the tournament, but he said he wanted his team to play without pressure as their campaign gets underway with many fancying the Azzurri to go a long way in the tournament.

“We must respect Turkey, they are a side full of talent,” he said.

“The opener is always difficult, and there will be plenty of emotions, but you can’t get too carried away.

“I don’t think there is an excess of enthusiasm. The fans can have that; we know who we are up against.

“The desire to be protagonists at this Euro is huge but this is a match to be played with lightheartedness. We can do it!”

6:08am: Tonight’s matchup will feature two teams in excellent form. Turkey are unbeaten from their last six outings, having won four and drawn two of their recent fixtures.

Italy, however, are in ominously strong form heading into the tournament. They’ve won each of their last eight matches, and will be hoping to kick off their Euro 2020 campaign with a ninth straight win tonight.

6:00pm: Good evening, and welcome to Express Sport’s live coverage of the opening match of Euro 2020, as Turkey take on Italy in Rome.

Per the draw, Turkey are technically the “home” side, but it’s Italy who will be playing on home soil, with the match taking place at the Stadio Olimpico in Rome.

We’ll bring you live updates throughout the night as we bring you the first night of 30 glorious days of top-level international football.

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Campaign underway to restore vandalized mural of transgender pioneer Marsha P. Johnson

ELIZABETH, New Jersey — A campaign is underway to restore a vandalized mural that honors a transgender activist.

The mural of Marsha P. Johnson was created in her hometown of Elizabeth, New Jersey, but someone painted over it in what activists call an act of hate.

Malcom Rolling painted the mural, and members of an LGBTQ+ youth group that organized the first Pride march in Elizabeth last year made the murals the focal point.

The group is called The People’s Committee of Elizabeth (TPCOE). Sister station WABC-TV in New York talked to one founding member, Priscilla Goana, who is in Hawaii right now.

“This is just a huge, huge slap in the face,” Goana said.

She says plans and fundraising are in the works to repaint the mural because it’s clearly needed.

“It’s targeted – it’s hatred and we don’t want that here,” said TPCOE activist Katherine Justiniano.

“This is a clear sign of transphobia, homophobia and racism,” TPCOE co-founder Natalie Hernandez said.

Johnson was 46 when she died in 1992 and was decades ahead of her time. The self-identified drag queen was a pioneering gay rights activist and a key figure in the Stonewall Uprising in 1969.

TPCOE is raising money on Instagram, Venmo and GoFundMe.

About $ 1,500 is needed just for the paint to reimagine what was once there, plus what the artist plans to add.

“I have something to say,” Rolling said. “Like I said, I’m a little furious, and I have something to say. And I want to be able to add to the mural to make it more robust.”

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Author: WABC

This post originally appeared on ABC13 RSS Feed

Lewis Hamilton contract deadline set by Mercedes boss Toto Wolff as talks appear underway

Seven-time world champion Lewis Hamilton is already in contract talks for 2022 with Mercedes, according to motorsport.com, with a deadline of June 15 set by boss Toto Wolff.

Speculation has surrounded Hamilton after he opted for a one-year deal with the Silver Arrows for 2021, with some suggesting he would choose to retire come the end of 2021, if he wins a record-breaking eighth world title.

According to reports, the 36-year-old is willing to agree on a wage cut in order to sort a new deal with the world champions.

It would run until the end of the 2022 season, with an option to extend it for another year, with Mercedes boss Wolff keen to sort it all by mid-June, to avoid lengthy contract negotiations.

Talks over the previous deal between Hamilton and Mercedes earlier this year dragged on throughout the winter and into spring.

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Finally, in February, Hamilton put pen to paper – but opted for just a year-long deal with the Silver Arrows, securing his future in F1 for another year.

This season, however, Hamilton claimed talks would happen much earlier, after they “ruined” his winter last time out, with his boss agreeing that this time around it’ll be done much earlier, and would be longer than a year.

“Yes, it should be [more than a year],” Wolff said. “We don’t want to be in a stressful situation every single year where we are absolutely flat-out trying to win races and needing to negotiate. I would rather that doesn’t happen every year.

“We just need to spend a day or two together, put it out there, and decide which are the difficult components. We will then lock the door and won’t walk out until it is sorted. That works best for us and it has worked best for us in the past.”

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This post originally appeared on Daily Express :: Sport Feed